Immunotherapy and radiation therapy for gastrointestinal malignancies: hope or hype?
Immunotherapy
cancer
radiation therapy
Journal
Translational gastroenterology and hepatology
ISSN: 2415-1289
Titre abrégé: Transl Gastroenterol Hepatol
Pays: China
ID NLM: 101683450
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
08
2019
accepted:
04
10
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Immunotherapy represents the newest pillar in cancer care. Although there are increasing data showing the efficacy of immunotherapy there is a spectrum of response across unselected populations of cancer patients. In fact, response rates can be poor even among patients with immunogenic tumors for reasons that remain poorly understood. A promising clinical strategy to improve outcomes, which is supported by an abundance of preclinical data, is combining immunotherapy with radiation therapy. Here we review the existing evidence and future directions for combining immunotherapy and radiation therapy for patients with gastrointestinal cancers.
Identifiants
pubmed: 32258525
doi: 10.21037/tgh.2019.10.07
pii: tgh-05-2019.10.07
pmc: PMC7063525
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
21Informations de copyright
2020 Translational Gastroenterology and Hepatology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no conflicts of interest to declare.
Références
Lancet Oncol. 2018 Jul;19(7):940-952
pubmed: 29875066
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
Lancet. 1999 Jan 30;353(9150):345-50
pubmed: 9950438
Oncol Lett. 2018 Apr;15(4):4988-4996
pubmed: 29552135
J Hepatol. 2013 Jul;59(1):81-8
pubmed: 23466307
Oncotarget. 2018 May 04;9(34):23482-23493
pubmed: 29805749
Oncoimmunology. 2014 May 14;3:e28780
pubmed: 25083318
Int J Radiat Oncol Biol Phys. 2003 Mar 15;55(4):930-42
pubmed: 12605971
Clin Cancer Res. 2019 Sep 15;25(18):5493-5502
pubmed: 31126960
Radiother Oncol. 2009 Aug;92(2):176-83
pubmed: 19586672
J Immunother. 2013 Sep;36(7):382-9
pubmed: 23924790
Oncotarget. 2017 Dec 27;9(17):13920-13933
pubmed: 29568405
Am J Clin Oncol. 2010 Aug;33(4):346-52
pubmed: 19841574
Cancer Sci. 2016 Apr;107(4):514-20
pubmed: 26782353
N Engl J Med. 2012 Jun 28;366(26):2455-65
pubmed: 22658128
Sci Rep. 2016 Nov 28;6:37933
pubmed: 27892511
Oncoimmunology. 2014 Dec 13;3(9):e955691
pubmed: 25941621
Lancet. 2017 Jun 24;389(10088):2492-2502
pubmed: 28434648
Eur J Cancer. 2014 Jan;50(1):121-7
pubmed: 24100024
Onco Targets Ther. 2017 Mar 29;10:1897-1908
pubmed: 28408841
Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):728-34
pubmed: 15701862
Clin Cancer Res. 2007 Apr 1;13(7):2151-7
pubmed: 17404099
Onco Targets Ther. 2016 Aug 12;9:5023-39
pubmed: 27574444
N Engl J Med. 2011 May 12;364(19):1817-25
pubmed: 21561347
CA Cancer J Clin. 2013 Sep;63(5):318-48
pubmed: 23856911
J Clin Oncol. 2000 Jan;18(1):148-57
pubmed: 10623705
Chin Clin Oncol. 2016 Oct;5(5):62
pubmed: 27829276
Ann Surg. 1995 Jun;221(6):721-31; discussion 731-3
pubmed: 7794076
Gastroenterology. 2015 Jun;148(7):1383-91.e6
pubmed: 25747273
Int J Radiat Oncol Biol Phys. 2018 Apr 1;100(5):1175-1178
pubmed: 29722659
Hum Vaccin Immunother. 2016 Mar 3;12(3):563-75
pubmed: 26619245
J Gastrointest Surg. 2006 Nov;10(9):1199-210; discussion 1210-1
pubmed: 17114007
Genet Mol Res. 2015 Feb 02;14(1):898-905
pubmed: 25730028
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Ann Surg. 2018 Jul;268(1):1-8
pubmed: 29334562
Am J Cancer Res. 2018 Jan 01;8(1):106-119
pubmed: 29416924
Ann Surg Oncol. 2017 Aug;24(8):2252-2258
pubmed: 28337660
Cancers (Basel). 2018 Nov 28;10(12):
pubmed: 30486519
BMC Cancer. 2018 Sep 10;18(1):877
pubmed: 30200910
Lancet Oncol. 2017 Apr;18(4):446-453
pubmed: 28223062
Oncologist. 2019 Oct;24(10):1340-1347
pubmed: 31040255
Ann Oncol. 2017 May 1;28(5):1036-1041
pubmed: 28453692
Pancreas. 2004 Jan;28(1):e26-31
pubmed: 14707745
Oncol Lett. 2018 Aug;16(2):2063-2070
pubmed: 30008901
J Clin Invest. 2014 Feb;124(2):687-95
pubmed: 24382348
PLoS Med. 2010 Apr 20;7(4):e1000267
pubmed: 20422030
Nat Med. 2018 May;24(5):541-550
pubmed: 29686425
Cancer Sci. 2009 Aug;100(8):1403-7
pubmed: 19496787
Front Immunol. 2018 Sep 07;9:2030
pubmed: 30245691
J Clin Oncol. 2018 Mar 10;36(8):773-779
pubmed: 29355075
J Clin Oncol. 2012 Jul 1;30(19):2327-33
pubmed: 22585691
J Immunol. 2001 Sep 1;167(5):2666-70
pubmed: 11509609
Cancer Immunol Res. 2014 Jul;2(7):616-31
pubmed: 24942756
JAMA Oncol. 2020 Jun 1;6(6):888-894
pubmed: 32352498
Cancer Cell. 2013 Nov 11;24(5):589-602
pubmed: 24209604
J Natl Cancer Inst. 2017 Jan 28;109(6):
pubmed: 28131992
PLoS One. 2018 Jun 6;13(6):e0198347
pubmed: 29874279
Int J Surg. 2018 Mar;51:120-127
pubmed: 29413875
J Hematol Oncol. 2018 Aug 16;11(1):104
pubmed: 30115069
Nat Med. 2007 Sep;13(9):1050-9
pubmed: 17704786
Cancer. 2003 Nov 15;98(10):2177-83
pubmed: 14601087
Cancer Res. 2010 Apr 1;70(7):2697-706
pubmed: 20215523
Oncoimmunology. 2018 Apr 9;7(8):e1450128
pubmed: 30221039
J Hepatol. 2018 Jul;69(1):182-236
pubmed: 29628281
Am J Pathol. 1999 Aug;155(2):537-47
pubmed: 10433946
Cancer Biol Ther. 2017 Jan 2;18(1):36-42
pubmed: 27905824
J Clin Oncol. 2019 Oct 20;37(30):2759-2768
pubmed: 31408414
J Immunother Cancer. 2019 May 16;7(1):128
pubmed: 31097034
Lancet Gastroenterol Hepatol. 2018 Feb;3(2):114-124
pubmed: 29248399
J Immunother. 2010 Oct;33(8):828-33
pubmed: 20842054
Cytotherapy. 2015 Dec;17(12):1746-62
pubmed: 26455275
Oncotarget. 2016 Feb 16;7(7):7913-24
pubmed: 26761210
Blood. 2009 Jul 16;114(3):589-95
pubmed: 19349616
Lancet Oncol. 2017 Sep;18(9):1182-1191
pubmed: 28734759
Oncotarget. 2017 Jun 20;8(25):41242-41255
pubmed: 28465485
Hepat Oncol. 2018 Sep 28;5(2):HEP08
pubmed: 31293776
N Engl J Med. 2006 Jul 6;355(1):11-20
pubmed: 16822992
Transl Lung Cancer Res. 2017 Apr;6(2):159-168
pubmed: 28529898
Lancet Oncol. 2015 Sep;16(9):1090-1098
pubmed: 26254683
J Clin Oncol. 1993 Mar;11(3):390-9
pubmed: 8445413
N Engl J Med. 2018 Dec 20;379(25):2395-2406
pubmed: 30575490
World J Gastroenterol. 2002 Jun;8(3):464-8
pubmed: 12046071
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
JAMA Oncol. 2019 Oct 01;5(10):1431-1438
pubmed: 31318392
J Surg Res. 1981 Apr;30(4):409-15
pubmed: 7230788
Front Med. 2019 Feb;13(1):3-11
pubmed: 30659408
Gastroenterology. 2008 Jul;135(1):234-43
pubmed: 18485901
Science. 2017 Jul 28;357(6349):409-413
pubmed: 28596308
J Exp Med. 2006 May 15;203(5):1259-71
pubmed: 16636135
Lancet. 2019 May 11;393(10184):1948-1957
pubmed: 30982686
Cancers (Basel). 2019 Feb 01;11(2):
pubmed: 30717285
Oncotarget. 2014 Jan 30;5(2):403-16
pubmed: 24480782
Oncology. 2012;82(6):347-51
pubmed: 22677933
Cancer Immunol Immunother. 2012 Dec;61(12):2251-9
pubmed: 22674056