Hip displacement in Wolf-Hirschhorn syndrome: Report on three cases and review of associated musculoskeletal pathologies.
Monosomy 4p-
Wolf-Hirschhorn Syndrome
congenital disease
delayed union
hip displacement
hip surveillance
Journal
American journal of medical genetics. Part A
ISSN: 1552-4833
Titre abrégé: Am J Med Genet A
Pays: United States
ID NLM: 101235741
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
11
10
2019
revised:
18
12
2019
accepted:
16
03
2020
pubmed:
8
4
2020
medline:
29
1
2021
entrez:
8
4
2020
Statut:
ppublish
Résumé
Wolf-Hirschhorn syndrome is a rare genetic disease caused by a chromosomal deletion of the distal short arm of Chromosome 4. It is associated with multisystem abnormalities, including delayed growth, characteristic facial features, epilepsy, and skeletal abnormalities. We report three patients who developed hip displacement, and describe the occurrence of delayed and nonunion in patients who underwent corrective proximal femoral osteotomy for hip displacement. We also performed a literature review identifying common musculoskeletal presentations associated with the condition. Patients with Wolf-Hirschhorn Syndrome are at risk of hip displacement (subluxation), and we would advocate annual hip surveillance in this patient group.
Identifiants
pubmed: 32259397
doi: 10.1002/ajmg.a.61573
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1449-1453Informations de copyright
© 2020 Wiley Periodicals, Inc.
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