DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.

Animals DNA Glycosylases / genetics DNA Repair Genomics Mice Prion Diseases Spleen / metabolism

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
20 05 2020
Historique:
received: 21 02 2020
revised: 19 03 2020
accepted: 29 03 2020
pubmed: 8 4 2020
medline: 22 6 2021
entrez: 8 4 2020
Statut: ppublish

Résumé

The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded DNA of transcriptionally active genes. Mice with genetic ablation of Neil2 (Neil2

Identifiants

DOI: 10.1016/j.freeradbiomed.2020.03.030 PMID: 32259578
pubmed: 32259578
pii: S0891-5849(20)30479-2
doi: 10.1016/j.freeradbiomed.2020.03.030
pii:
doi:

Substances chimiques

DNA Glycosylases EC 3.2.2.-
Neil2 protein, mouse EC 3.2.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

348-354

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing financial interests.

Auteurs

Katja Scheffler (K)

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neurology, St. Olavs Hospital, Trondheim, Norway; Department of Laboratory Medicine, St. Olavs Hospital, Trondheim, Norway. Electronic address: katja.scheffler@ntnu.no.

Clara M O Jalland (CMO)

Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Campus Adamstuen, Oslo, Norway.

Sylvie L Benestad (SL)

Norwegian Veterinary Institute, Oslo, Norway.

Torfinn Moldal (T)

Norwegian Veterinary Institute, Oslo, Norway.

Cecilie Ersdal (C)

Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Campus Sandnes, Norway.

Gjermund Gunnes (G)

Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Campus Adamstuen, Oslo, Norway.

Rajikala Suganthan (R)

Department of Microbiology, Oslo University Hospital and University of Oslo, Norway.

Magnar Bjørås (M)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Laboratory Medicine, St. Olavs Hospital, Trondheim, Norway; Department of Microbiology, Oslo University Hospital and University of Oslo, Norway.

Michael A Tranulis (MA)

Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Campus Adamstuen, Oslo, Norway.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › DNA glycosylase Neil2 contributes to genomic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › N-Glycosyl hydrolases › DNA Glycosylases › DNA glycosylase Neil2 contributes to genomic...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › DNA glycosylase Neil2 contributes to genomic...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › DNA glycosylase Neil2 contributes to genomic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › DNA glycosylase Neil2 contributes to genomic...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladies à prions › DNA glycosylase Neil2 contributes to genomic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › DNA glycosylase Neil2 contributes to genomic...