NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Apoptosis Cells, Cultured Disease Models, Animal Dopaminergic Neurons / pathology Glia Maturation Factor / genetics Humans Inflammasomes / metabolism Mice Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Neurogenic Inflammation Neuroglia / physiology Parkinson Disease / immunology
GMF MPTP NLRP3 inflammasome Parkinson’s disease

Journal

International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 22 01 2020
revised: 10 03 2020
accepted: 22 03 2020
pubmed: 8 4 2020
medline: 9 3 2021
entrez: 8 4 2020
Statut: ppublish

Résumé

Neuroinflammation plays an active role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD). Earlier studies from this laboratory showed that glia maturation factor (GMF), a proinflammatory mediator; is up-regulated in the brain in neurodegenerative diseases and that deficiency of GMF showed decreased production of IL-1β and improved behavioral abnormalities in mouse model of PD. However, the mechanisms linking GMF and dopaminergic neuronal death have not been completely explored. In the present study, we have investigated the expression of NLRP3 inflammasome and caspase-1 in the substantia nigra (SN) of human PD and non-PD brains by immunohistochemistry. Wild-type (WT) and GMF

Identifiants

DOI: 10.1016/j.intimp.2020.106441 PMID: 32259702 PMC: PMC7255416
pubmed: 32259702
pii: S1567-5769(20)30220-4
doi: 10.1016/j.intimp.2020.106441
pmc: PMC7255416
mid: NIHMS1582559
pii:
doi:

Substances chimiques

Glia Maturation Factor 0
Inflammasomes 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 9P21XSP91P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106441

Subventions

Organisme : BLRD VA
ID : I01 BX002477
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048205
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

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Auteurs

Hayate Javed (H)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Anatomy, College of Medicine and Health Science, United Arab Emirates University, Al Ain, PO Box 17666, United Arab Emirates.

Ramasamy Thangavel (R)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Govindhasamy Pushpavathi Selvakumar (GP)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Iuliia Dubova (I)

Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Noah Schwartz (N)

Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA.

Mohammad Ejaz Ahmed (ME)

Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Smita Zaheer (S)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Duraisamy Kempuraj (D)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Shankar Iyer (S)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Asgar Zaheer (A)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA. Electronic address: zaheera@health.missouri.edu.

Mohammad Moshahid Khan (MM)

Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Division of Rehabilitation Sciences and Department of Physical Therapy, College of Health Professions, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: mkhan26@uthsc.edu.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Eucaryotes › Animaux › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Cellules › Cellules cultivées › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur de maturation gliale › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Inflammation neurogénique › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Cellules › Névroglie › NLRP3 inflammasome and glia maturation factor...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › NLRP3 inflammasome and glia maturation factor...