Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review.
drug metabolism
drug toxicity
organ-on-a-chip
Journal
Micromachines
ISSN: 2072-666X
Titre abrégé: Micromachines (Basel)
Pays: Switzerland
ID NLM: 101640903
Informations de publication
Date de publication:
03 Apr 2020
03 Apr 2020
Historique:
received:
01
03
2020
revised:
20
03
2020
accepted:
25
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology.
Identifiants
pubmed: 32260191
pii: mi11040381
doi: 10.3390/mi11040381
pmc: PMC7230535
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 21675017
Organisme : National Key Research and Development Program of China
ID : 2017YFC1702001
Organisme : Shenzhen Fundamental Research and Discipline Layout project
ID : JCYJ2018050815247476
Organisme : China Postdoctoral Science Foundation
ID : 21675017
Organisme : Sanming Project of Medicine in Shenzhen
ID : SZSM201612049
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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