Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug.
antimicrobial properties
chitosan
electrospinning
fibroblasts proliferation
glycosaminoglycans
scaffolds
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
04 Apr 2020
04 Apr 2020
Historique:
received:
24
02
2020
revised:
26
03
2020
accepted:
27
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Infections in nonhealing wounds remain one of the major challenges. Recently, nanomedicine approach seems a valid option to overcome the antibiotic resistance mechanisms. The aim of this study was the development of three types of polysaccharide-based scaffolds (chitosan-based (CH), chitosan/chondroitin sulfate-based (CH/CS), chitosan/hyaluronic acid-based (CH/HA)), as dermal substitutes, to be loaded with norfloxacin, intended for the treatment of infected wounds. The scaffolds have been loaded with norfloxacin as a free drug (N scaffolds) or in montmorillonite nanocomposite (H-hybrid-scaffolds). Chitosan/glycosaminoglycan (chondroitin sulfate or hyaluronic acid) scaffolds were prepared by means of electrospinning with a simple, one-step process. The scaffolds were characterized by 500 nm diameter fibers with homogeneous structures when norfloxacin was loaded as a free drug. On the contrary, the presence of nanocomposite caused a certain degree of surface roughness, with fibers having 1000 nm diameters. The presence of norfloxacin-montmorillonite nanocomposite (1%) caused higher deformability (90%-120%) and lower elasticity (5-10 mN/cm
Identifiants
pubmed: 32260441
pii: pharmaceutics12040325
doi: 10.3390/pharmaceutics12040325
pmc: PMC7238150
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Horizon 2020 Research and Innovation Programme
ID : 814607
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Pharmaceutics. 2020 Feb 20;12(2):
pubmed: 32093190
Interv Med Appl Sci. 2016 Jun 1;8(2):68-76
pubmed: 28386462
Carbohydr Polym. 2014 Feb 15;102:970-7
pubmed: 24507371
Pharm Nanotechnol. 2016;4(3):191-201
pubmed: 29052498
Dermatol Clin. 1993 Oct;11(4):647-66
pubmed: 8222349
Int J Pharm Compd. 2000 May-Jun;4(3):223-4
pubmed: 23986005
Acta Biomater. 2017 Jul 15;57:216-224
pubmed: 28522411
Trends Microbiol. 2019 Nov;27(11):915-926
pubmed: 31420126
Carbohydr Polym. 2018 Mar 15;184:408-417
pubmed: 29352936
Postepy Dermatol Alergol. 2013 Oct;30(5):302-6
pubmed: 24353490
Molecules. 2018 Mar 23;23(4):
pubmed: 29570644
J Pharm Sci. 2008 Aug;97(8):2892-923
pubmed: 17963217
Clin Dermatol. 2010 Sep-Oct;28(5):519-26
pubmed: 20797512
Chem Soc Rev. 2019 Jan 21;48(2):415-427
pubmed: 30462112
J Tissue Eng Regen Med. 2009 Feb;3(2):77-84
pubmed: 19051218
Eur J Pharm Sci. 2016 Feb 15;83:155-65
pubmed: 26733072
J Int Med Res. 2009 Sep-Oct;37(5):1528-42
pubmed: 19930861
Eur J Pharm Biopharm. 2019 Sep;142:247-257
pubmed: 31265896
Carbohydr Polym. 2019 Sep 15;220:219-227
pubmed: 31196543
J Biomater Appl. 2004 Apr;18(4):291-303
pubmed: 15070516
Colloids Surf B Biointerfaces. 2014 Jan 1;113:152-7
pubmed: 24077113
Antimicrob Agents Chemother. 1983 Jan;23(1):15-8
pubmed: 6219617
Cell J. 2020 Jan;21(4):379-390
pubmed: 31376319
Pharm Res. 1994 Apr;11(4):522-7
pubmed: 8058609
Int J Nanomedicine. 2019 Jul 10;14:5051-5060
pubmed: 31371946
Molecules. 2019 Apr 01;24(7):
pubmed: 30939857
Polymers (Basel). 2019 Jul 19;11(7):
pubmed: 31330974
Pharm Dev Technol. 2007;12(4):415-22
pubmed: 17763146
Expert Opin Drug Deliv. 2015 Apr;12(4):525-45
pubmed: 25297510
Drug Des Devel Ther. 2019 Jan 18;13:327-343
pubmed: 30705582
Anal Bioanal Chem. 2003 Mar;375(5):623-9
pubmed: 12638045
J Appl Microbiol. 2013 Aug;115(2):382-9
pubmed: 23647563
Mol Biol Rep. 2018 Dec;45(6):2857-2867
pubmed: 30094529
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):228-240
pubmed: 30688107
Nanomedicine (Lond). 2017 Jun;12(11):1335-1352
pubmed: 28520509
Mater Sci Eng C Mater Biol Appl. 2017 May 1;74:146-151
pubmed: 28254279
Br J Surg. 2017 Jan;104(2):e85-e94
pubmed: 28121033