Exploring Perinatal Asphyxia by Metabolomics.
1H NMR
GC-MS
LC-MS
hypoxic-ischemic encephalopathy
metabolomics
perinatal asphyxia
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
04 Apr 2020
04 Apr 2020
Historique:
received:
28
02
2020
revised:
25
03
2020
accepted:
02
04
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Brain damage related to perinatal asphyxia is the second cause of neuro-disability worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide, with no further recent improvement even in more industrialized countries. If so, hypoxic-ischemic encephalopathy is still an issue of global health concern. It is thought that a consistent number of cases may be avoided, and its sequelae may be preventable by a prompt and efficient physical and therapeutic treatment. The lack of early, reliable, and specific biomarkers has up to now hampered a more effective use of hypothermia, which represents the only validated therapy for this condition. The urge to unravel the biological modifications underlying perinatal asphyxia and hypoxic-ischemic encephalopathy needs new diagnostic and therapeutic tools. Metabolomics for its own features is a powerful approach that may help for the identification of specific metabolic profiles related to the pathological mechanism and foreseeable outcome. The metabolomic profiles of animal and human infants exposed to perinatal asphyxia or developing hypoxic-ischemic encephalopathy have so far been investigated by means of
Identifiants
pubmed: 32260446
pii: metabo10040141
doi: 10.3390/metabo10040141
pmc: PMC7240960
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Pediatr Res. 2018 Jan;83(1-2):356-363
pubmed: 29016557
Biomed Res Int. 2014;2014:731620
pubmed: 24696864
Ann Transl Med. 2016 Nov;4(21):417
pubmed: 27942508
Anesthesiology. 2009 Sep;111(3):533-46
pubmed: 19672176
Lancet. 2005 Feb 19-25;365(9460):663-70
pubmed: 15721471
JAMA Pediatr. 2015 Apr;169(4):397-403
pubmed: 25685948
PLoS One. 2012;7(12):e50520
pubmed: 23227182
Brain Res. 2004 Sep 24;1021(2):167-72
pubmed: 15342264
PLoS One. 2016 Aug 16;11(8):e0161123
pubmed: 27529347
Handb Clin Neurol. 2019;162:281-293
pubmed: 31324315
Sci Rep. 2017 Jan 10;7:40315
pubmed: 28071721
J Proteome Res. 2013 Sep 6;12(9):4230-9
pubmed: 23931672
Sci Rep. 2017 Nov 29;7(1):16575
pubmed: 29185486
Brain Res. 2005 May 31;1045(1-2):22-30
pubmed: 15910759
N Engl J Med. 2009 Oct 1;361(14):1349-58
pubmed: 19797281
Redox Biol. 2017 Aug;12:1-7
pubmed: 28209514
Nature. 2014 Nov 20;515(7527):431-435
pubmed: 25383517
J Pediatr. 2014 Mar;164(3):438-40
pubmed: 24388328
Pediatr Res. 1996 Apr;39(4 Pt 1):584-90
pubmed: 8848329
N Engl J Med. 2005 Oct 13;353(15):1574-84
pubmed: 16221780
PLoS One. 2013 Jun 18;8(6):e66540
pubmed: 23823578
Early Hum Dev. 2010 Jun;86(6):361-7
pubmed: 20570448
Clin Biochem. 2006 Mar;39(3):203-9
pubmed: 16460720
PLoS One. 2018 Apr 18;13(4):e0194267
pubmed: 29668681
J Pediatr. 2010 Sep;157(3):367-72, 372.e1-3
pubmed: 20488453
Neonatology. 2016;110(4):296-302
pubmed: 27486995
Dev Neurosci. 2017;39(1-4):107-123
pubmed: 28343228
Front Pediatr. 2019 Oct 01;7:399
pubmed: 31632939
Sci Rep. 2017 Dec 6;7(1):17039
pubmed: 29213095
Curr Opin Pediatr. 2018 Apr;30(2):199-203
pubmed: 29346139
J Chromatogr A. 2011 Apr 8;1218(14):1899-906
pubmed: 21353677
Dev Neurosci. 2015;37(2):161-71
pubmed: 25765047
Pediatr Res. 2013 Aug;74(2):170-9
pubmed: 23708689
Acta Paediatr. 2020 Jan;109(1):200-201
pubmed: 31432551
Anesthesiology. 2013 Nov;119(5):1120-36
pubmed: 23748856
PLoS One. 2013 May 31;8(5):e65035
pubmed: 23741447
Brain Dev. 2009 Jan;31(1):1-10
pubmed: 18490122
Cell Rep. 2018 May 29;23(9):2617-2628
pubmed: 29847793
Pediatrics. 2010 Oct;126(4):e771-8
pubmed: 20855387
J Matern Fetal Neonatal Med. 2018 Jun;31(11):1462-1469
pubmed: 28412875
Clin Chim Acta. 2015 Apr 15;444:250-6
pubmed: 25727514
J Pediatr. 2011 Nov;159(5):851-858.e1
pubmed: 21875719
J Cereb Blood Flow Metab. 2011 Feb;31(2):547-59
pubmed: 20717124
Semin Pediatr Neurol. 2019 Dec;32:100773
pubmed: 31813519
Pediatr Res. 2014 Aug;76(2):127-34
pubmed: 24819373
Arch Neurol. 1976 Oct;33(10):696-705
pubmed: 987769
Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1602-7
pubmed: 19164545
PLoS One. 2010 Mar 09;5(3):e9606
pubmed: 20231903
Front Neurol. 2020 Feb 25;11:133
pubmed: 32161566
Pediatr Res. 2016 Aug;80(2):284-92
pubmed: 27055187
J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:134-7
pubmed: 20873980
Anesthesiology. 2004 Sep;101(3):695-703
pubmed: 15329594
N Engl J Med. 2004 Nov 4;351(19):1985-95
pubmed: 15525724
Pediatrics. 2009 Aug;124(2):e218-26
pubmed: 19651565
Pediatr Res. 2001 May;49(5):698-704
pubmed: 11328955