Japanese guidelines for atopic dermatitis 2020.
Atopic dermatitis
Clinical practice guidelines
Eczema
Evidence-based medicine
Treatment
Journal
Allergology international : official journal of the Japanese Society of Allergology
ISSN: 1440-1592
Titre abrégé: Allergol Int
Pays: England
ID NLM: 9616296
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
24
12
2019
revised:
26
02
2020
accepted:
26
02
2020
pubmed:
9
4
2020
medline:
20
8
2021
entrez:
9
4
2020
Statut:
ppublish
Résumé
Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion, which is frequently encountered in clinical practice. Skin barrier dysfunction leads to enhanced skin irritability to non-specific stimuli and epicutaneous sensitization. In the lesion site, a further inflammation-related reduction in skin barrier function, enhanced irritability and scratching-related stimuli deteriorate eczema, leading to vicious cycle of inflammation. The current strategies to treat AD in Japan from the perspective of evidence-based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice.
Identifiants
pubmed: 32265116
pii: S1323-8930(20)30018-6
doi: 10.1016/j.alit.2020.02.006
pii:
doi:
Types de publication
Journal Article
Practice Guideline
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-369Informations de copyright
Copyright © 2020 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.