Upregulation of Glutamic-Oxaloacetic Transaminase 1 Predicts Poor Prognosis in Acute Myeloid Leukemia.
acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
chemotherapy
glutamate oxaloacetate transaminase 1
prognosis
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
07
2019
accepted:
04
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
One of the key features of acute myeloid leukemia (AML), a group of very aggressive myeloid malignancies, is their strikingly heterogenous outcomes. Accurate biomarkers are needed to improve prognostic assessment. Glutamate oxaloacetate transaminase 1 (GOT1) is essential for cell proliferation and apoptosis by regulating cell's metabolic dependency on glucose. It is unclear whether the expression level of
Identifiants
pubmed: 32266153
doi: 10.3389/fonc.2020.00379
pmc: PMC7105742
doi:
Types de publication
Journal Article
Langues
eng
Pagination
379Informations de copyright
Copyright © 2020 Cheng, Dai, Zeng, Liu, Cui, Qian, Si, Huang, Pang, Ye, Shi and Fu.
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