Decellularized Human Dermal Matrix as a Biological Scaffold for Cardiac Repair and Regeneration.
biological scaffolds
cardiac tissue engineering/regenerative medicine
decellularized extracellular matrix
human cardiac progenitor cells
human dermal matrix
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
11
2019
accepted:
05
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
The complex and highly organized environment in which cells reside consists primarily of the extracellular matrix (ECM) that delivers biological signals and physical stimuli to resident cells. In the native myocardium, the ECM contributes to both heart compliance and cardiomyocyte maturation and function. Thus, myocardium regeneration cannot be accomplished if cardiac ECM is not restored. We hypothesize that decellularized human skin might make an easily accessible and viable alternate biological scaffold for cardiac tissue engineering (CTE). To test our hypothesis, we decellularized specimens of both human skin and human myocardium and analyzed and compared their composition by histological methods and quantitative assays. Decellularized dermal matrix was then cut into 600-μm-thick sections and either tested by uniaxial tensile stretching to characterize its mechanical behavior or used as three-dimensional scaffold to assess its capability to support regeneration by resident cardiac progenitor cells (hCPCs)
Identifiants
pubmed: 32266249
doi: 10.3389/fbioe.2020.00229
pmc: PMC7099865
doi:
Types de publication
Journal Article
Langues
eng
Pagination
229Informations de copyright
Copyright © 2020 Belviso, Romano, Sacco, Ricci, Massai, Cammarota, Catizone, Schiraldi, Nurzynska, Terzini, Aldieri, Serino, Schonauer, Sirico, D’Andrea, Montagnani, Di Meglio and Castaldo.
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