Primary Mammary Organoid Model of Lactation and Involution.
3D culture
fibroblast growth factor 2
involution
lactation
mammary gland
milk production
organoid
prolactin
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
11
2019
accepted:
24
01
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
Identifiants
pubmed: 32266252
doi: 10.3389/fcell.2020.00068
pmc: PMC7098375
doi:
Types de publication
Journal Article
Langues
eng
Pagination
68Informations de copyright
Copyright © 2020 Sumbal, Chiche, Charifou, Koledova and Li.
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