Design, synthesis, in silico studies and biological evaluation of 5-((
Antimicrobial
Antioxidant
Characterization
Synthesis
Thiazolidin-2,4-dione
Journal
BMC chemistry
ISSN: 2661-801X
Titre abrégé: BMC Chem
Pays: Switzerland
ID NLM: 101741142
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
16
01
2020
accepted:
19
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Looking at the extensive biological potential of thiazolidine-2,4-dione (TZD) moiety, a new series of thiazolidine-2,4-dione analogues was synthesized. Different spectral techniques ( The antimicrobial screening was carried out against selected strains of fungi and bacteria using serial tube dilution method. The antioxidant potential was assessed using stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Further, the interaction between synthesized thiazolidine-2,4-dione compounds and DNA gyrase was explored using molecular docking studies. Various ADME parameters were also studied to evaluate the drug likeness of the synthesized compounds. In antimicrobial evaluation, the compounds
Sections du résumé
BACKGROUND
BACKGROUND
Looking at the extensive biological potential of thiazolidine-2,4-dione (TZD) moiety, a new series of thiazolidine-2,4-dione analogues was synthesized. Different spectral techniques (
RESULTS AND DISCUSSION
CONCLUSIONS
The antimicrobial screening was carried out against selected strains of fungi and bacteria using serial tube dilution method. The antioxidant potential was assessed using stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Further, the interaction between synthesized thiazolidine-2,4-dione compounds and DNA gyrase was explored using molecular docking studies. Various ADME parameters were also studied to evaluate the drug likeness of the synthesized compounds.
CONCLUSION
CONCLUSIONS
In antimicrobial evaluation, the compounds
Identifiants
pubmed: 32266332
doi: 10.1186/s13065-020-00678-2
pii: 678
pmc: PMC7110766
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestThe authors have no competing interest.
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