Daylight photodynamic therapy for the management of actinic cheilitis.
Aged
Aged, 80 and over
Aminolevulinic Acid
/ administration & dosage
Carcinoma, Squamous Cell
/ pathology
Cheilitis
/ drug therapy
Female
Follow-Up Studies
Humans
Lip Neoplasms
/ pathology
Male
Middle Aged
Photochemotherapy
/ adverse effects
Photosensitizing Agents
/ administration & dosage
Precancerous Conditions
/ drug therapy
Skin Cream
/ administration & dosage
Treatment Outcome
Actinic cheilitis
Daylight
Daylight photodynamic therapy
Photodynamic therapy
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
08
12
2019
accepted:
30
03
2020
pubmed:
9
4
2020
medline:
16
6
2021
entrez:
9
4
2020
Statut:
ppublish
Résumé
Early identification and adequate treatment of actinic cheilitis (AC), which affects the lower lip vermillion and is considered a precursor of squamous cell carcinoma, is mandatory. Photodynamic therapy (PDT) has been successfully used in AC. PDT with the use of daylight (DLPDT) is equally effective and more convenient than the conventional PDT. Data on short and long-term efficacy of DLPDT in AC are limited. Our primary purpose was to assess efficacy of DLPDT in AC as well as safety and tolerance. Twenty-two individuals with histologically confirmed AC received 2 MAL (5-aminolevulinic acid)-DLPDT sessions 1 week apart. Patients were evaluated clinically 3, 6, and 12 months after treatment. Non-complete responders were biopsied and excluded from the study if histological alterations were indicative of AC. Adverse events were recorded from baseline to the end of the 12-month follow-up period. Twenty patients completed the study. Overall, complete clinical response 12 months after treatment was 80% (16/20), while an association between treatment response and grade of dysplasia was observed (p = 0.016). With respect to response by grade, complete clinical response achieved in grade I AC was 100% (12/12) and 50% (4/8) in grade II AC. Main adverse events included mild erythema, oedema, and scaling, with no pain associated with DLPDT. According to our results, DLPDT seems to be of significant benefit for the treatment of grade I AC. Combination with the other treatment modalities could improve the efficacy in grade II AC. Further studies are needed for the assessment of late recurrences.
Identifiants
pubmed: 32266532
doi: 10.1007/s00403-020-02069-y
pii: 10.1007/s00403-020-02069-y
doi:
Substances chimiques
Photosensitizing Agents
0
delta-aminolevulinic acid methyl ester
0
Aminolevulinic Acid
88755TAZ87
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
731-737Commentaires et corrections
Type : CommentIn
Références
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