Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments.
Astrobiology
C. elegans—
Space biology
Spaceflight
Journal
Astrobiology
ISSN: 1557-8070
Titre abrégé: Astrobiology
Pays: United States
ID NLM: 101088083
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
9
4
2020
medline:
27
7
2021
entrez:
9
4
2020
Statut:
ppublish
Résumé
Biology experiments in space seek to increase our understanding of what happens to life beyond Earth and how we can safely send life beyond Earth. Spaceflight is associated with many (mal)adaptations in physiology, including decline in musculoskeletal, cardiovascular, vestibular, and immune systems. Biological experiments in space are inherently challenging to implement. Development of hardware and validation of experimental conditions are critical to ensure the collection of high-quality data. The model organism
Identifiants
pubmed: 32267726
doi: 10.1089/ast.2019.2181
pmc: PMC7415877
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
935-943Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015894/1
Pays : United Kingdom
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P025781/1
Pays : United Kingdom
Références
Nat Commun. 2015 Feb 19;6:6345
pubmed: 25695879
Front Physiol. 2018 Nov 12;9:1551
pubmed: 30483144
FASEB J. 2001 Apr;15(6):1104-6
pubmed: 11292682
NPJ Microgravity. 2016 Jan 21;2:15022
pubmed: 28725720
Sci Rep. 2012;2:487
pubmed: 22768380
J Vis Exp. 2014 Nov 13;(93):e52043
pubmed: 25489753
Sports Med Open. 2017 Nov 13;3(1):40
pubmed: 29134470
Adv Space Res. 2013 Jun 1;51(12):2241-2250
pubmed: 23794777
Adv Space Res. 2008;41(5):807-815
pubmed: 18392117
Prog Mol Biol Transl Sci. 2015;135:355-80
pubmed: 26477922
J Appl Physiol (1985). 2009 Apr;106(4):1159-68
pubmed: 19150852
J R Soc Interface. 2012 Mar 7;9(68):596-9
pubmed: 22130552
Nat Protoc. 2016 Oct;11(10):1798-816
pubmed: 27583642
Genetics. 2015 Jun;200(2):387-407
pubmed: 26088431
J Physiol. 2010 Sep 15;588(Pt 18):3567-92
pubmed: 20660569
Annu Rev Food Sci Technol. 2018 Mar 25;9:1-22
pubmed: 29261338
Gerontology. 2014;60(2):138-42
pubmed: 24217152
BMC Biotechnol. 2003 Oct 27;3:19
pubmed: 14580264
Astrobiology. 2005 Dec;5(6):690-705
pubmed: 16379525
Front Physiol. 2017 Aug 02;8:547
pubmed: 28824446
Aging (Albany NY). 2018 Nov 19;10(11):3382-3396
pubmed: 30455409
Biol Sci Space. 2009 Oct 1;23(4):183-187
pubmed: 20729992
J Exp Biol. 2006 Oct;209(Pt 20):4129-39
pubmed: 17023606
Adv Space Res. 2008 Sep 15;42(6):1072-1079
pubmed: 22146801
Dis Model Mech. 2018 Dec 4;11(12):
pubmed: 30396907
Nat Rev Drug Discov. 2006 May;5(5):387-98
pubmed: 16672925