The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design.
Anti-Bacterial Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
Betacoronavirus
COVID-19
Community-Acquired Infections
/ therapy
Coronavirus Infections
/ therapy
Evidence-Based Medicine
Humans
Influenza, Human
/ therapy
Pandemics
Pneumonia
/ therapy
Pneumonia, Viral
/ therapy
Point-of-Care Systems
SARS-CoV-2
Bayesian adaptive
community-acquired pneumonia
coronavirus disease 2019
master protocol
platform trial
randomized clinical trial
Journal
Annals of the American Thoracic Society
ISSN: 2325-6621
Titre abrégé: Ann Am Thorac Soc
Pays: United States
ID NLM: 101600811
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
9
4
2020
medline:
12
9
2020
entrez:
9
4
2020
Statut:
ppublish
Résumé
There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale and design of a large, international trial that combines features of adaptive platform trials with pragmatic point-of-care trials to determine best treatment strategies for patients admitted to an intensive care unit with severe community-acquired pneumonia. The trial uses a novel design, entitled "a randomized embedded multifactorial adaptive platform." The design has five key features:
Identifiants
pubmed: 32267771
doi: 10.1513/AnnalsATS.202003-192SD
pmc: PMC7328186
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antiviral Agents
0
Banques de données
ClinicalTrials.gov
['NCT02735707']
Types de publication
Adaptive Clinical Trial
Clinical Trial Protocol
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
879-891Subventions
Organisme : Department of Health
ID : RP-2015-06-018
Pays : United Kingdom
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