Baccharis dracunculifolia (Asteraceae) essential oil displays anti-inflammatory activity in models of skin inflammation.
Animals
Anti-Inflammatory Agents
/ chemistry
Baccharis
/ chemistry
Drug Eruptions
/ drug therapy
Edema
/ chemically induced
Epidermis
/ pathology
Female
Lymphatic System
/ drug effects
Mice
Oils, Volatile
/ chemistry
Plant Extracts
/ pharmacology
Plant Leaves
/ chemistry
Receptors, Glucocorticoid
/ metabolism
Baccharis dracunculifolia
Essential oil
Inflammation
Skin
Journal
Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310
Informations de publication
Date de publication:
15 Sep 2020
15 Sep 2020
Historique:
received:
26
09
2019
revised:
23
03
2020
accepted:
01
04
2020
pubmed:
9
4
2020
medline:
26
2
2021
entrez:
9
4
2020
Statut:
ppublish
Résumé
Baccharis dracunculifolia (Asteraceae) is a commonly used plant in traditional medicine known as "alecrim-do-campo". Popularly it has been used as an immunostimulant, antibiotic, anti-inflammatory among other applications. So far, only a few studies have investigated the B. dracunculifolia anti-inflammatory effect and none has investigated the effectiveness of essential oil on skin diseases. The study aimed at evaluating the topical anti-inflammatory activity of B. dracunculifolia essential oil (BdEO) in mice models of acute and chronic skin inflammation. BdEO was obtained from leaves and it was analyzed with Gas Chromatograph. Topical anti-inflammatory activity of BdEO (0.1, 0.3 and 1.0 mg/ear) was evaluated in Arachidonic Acid or TPA-induced acute and chronic skin inflammation in mice. Parameters such edema, cell migration and keratinocytes proliferation were evaluated. In addition, safety and a possible mechanism of action for BdEO essential oil were also investigated. Our results indicate that mainly terpenoids compounds compose BdEO. In addition, topical treatment with BdEO inhibited inflammatory parameters in both acute and chronic models of skin inflammation. This protective effect was associated with reduced edema formation, smaller cellular influx into the inflamed tissue and reduction of keratinocytes hyperproliferation. Although BdEO appears to exert its anti-inflammatory effect through a corticosteroid pathway, no local or systemic side effects were observed. Taken together, the present results showed that the essential oil obtained by hydrodistillation from B. dracunculifolia leaf samples exhibit remarkable topical anti-inflammatory properties. Therefore, our study demonstrated evidence for BdEO topical anti-inflammatory efficacy and safety, suggesting that it could be considered for developing of a new phytotherapeutic formulation as treatment for skin diseases.
Identifiants
pubmed: 32268204
pii: S0378-8741(19)33842-5
doi: 10.1016/j.jep.2020.112840
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Oils, Volatile
0
Plant Extracts
0
Receptors, Glucocorticoid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112840Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare no conflict of interest.