Human Cytomegalovirus Infection Suppresses CD34
hematopoiesis
hematopoietic stem cell transplant
human cytomegalovirus
humanized mice
myelosuppression
progenitor cell
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
06 Apr 2020
06 Apr 2020
Historique:
received:
10
03
2020
revised:
03
04
2020
accepted:
04
04
2020
entrez:
10
4
2020
pubmed:
10
4
2020
medline:
10
4
2020
Statut:
epublish
Résumé
Human cytomegalovirus (HCMV) infection is a serious complication in hematopoietic stem cell transplant (HSCT) recipients due to virus-induced myelosuppression and impairment of stem cell engraftment. Despite the clear clinical link between myelosuppression and HCMV infection, little is known about the mechanism(s) by which the virus inhibits normal hematopoiesis because of the strict species specificity and the lack of surrogate animal models. In this study, we developed a novel humanized mouse model system that recapitulates the HCMV-mediated engraftment failure after hematopoietic cell transplantation. We observed significant alterations in the hematopoietic populations in peripheral lymphoid tissues following engraftment of a subset of HCMV
Identifiants
pubmed: 32268565
pii: microorganisms8040525
doi: 10.3390/microorganisms8040525
pmc: PMC7232458
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : P01 A127335
Pays : United States
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