Measuring Arterial Stiffness in Animal Experimental Studies.


Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
05 2020
Historique:
pubmed: 10 4 2020
medline: 15 7 2020
entrez: 10 4 2020
Statut: ppublish

Résumé

The arterial wall is a composite material of elastin, collagen, and extracellular matrix with acutely modifiable material properties through the action of smooth muscle cells. Therefore, arterial stiffness is a complex parameter that changes not only with long-term remodeling of the wall constituents but also with acute contraction or relaxation of smooth muscle or with changes in the acute distending pressure to which the artery is exposed. It is not possible to test all these aspects using noninvasive or even invasive techniques in humans. Full characterization of the mechanical properties of the artery and the specific arterial factors causing changes to stiffness with disease or modified lifestyle currently require animal studies. This article summarizes the major in vivo and ex vivo techniques to measure the different aspects of arterial stiffness in animal studies.

Identifiants

pubmed: 32268787
doi: 10.1161/ATVBAHA.119.313861
pmc: PMC7176337
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1068-1077

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Auteurs

Mark Butlin (M)

From the Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia (M.B., I.T., A.P.A.).

Isabella Tan (I)

From the Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia (M.B., I.T., A.P.A.).

Bart Spronck (B)

Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, CT (B.S.).
Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, the Netherlands (B.S.).

Alberto P Avolio (AP)

From the Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia (M.B., I.T., A.P.A.).

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Classifications MeSH