Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors:First Italian Clinical Trial.
Aged
Aspartate Aminotransferases
/ metabolism
Cold Temperature
Female
Graft Survival
Humans
Infusion Pumps
/ adverse effects
Kidney
/ metabolism
Kidney Transplantation
/ instrumentation
Liver
/ metabolism
Liver Transplantation
/ instrumentation
Male
Middle Aged
Organ Preservation
/ instrumentation
Oxygenators, Membrane
/ adverse effects
Perfusion
/ instrumentation
Tissue Donors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 04 2020
08 04 2020
Historique:
received:
12
12
2019
accepted:
04
03
2020
entrez:
10
4
2020
pubmed:
10
4
2020
medline:
26
11
2020
Statut:
epublish
Résumé
With the aim to explore innovative tools for organ preservation, especially in marginal organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion (HOPE) in the field of liver (LT) and kidney transplantation (KT) from Extended Criteria Donors (ECD) after brain death. A matched-case analysis of donor and recipient variables was developed: 10 HOPE-ECD livers and kidneys (HOPE-L and HOPE-K) were matched 1:3 with livers and kidneys preserved with static cold storage (SCS-L and SCS-K). HOPE and SCS groups resulted with similar basal characteristics, both for recipients and donors. Cumulative liver and kidney graft dysfunction were 10% (HOPE L-K) vs. 31.7%, in SCS group (p = 0.05). Primary non-function was 3.3% for SCS-L vs. 0% for HOPE-L. No primary non-function was reported in HOPE-K and SCS-K. Median peak aspartate aminotransferase within 7-days post-LT was significantly higher in SCS-L when compared to HOPE-L (637 vs.344 U/L, p = 0.007). Graft survival at 1-year post-transplant was 93.3% for SCS-L vs. 100% of HOPE-L and 90% for SCS-K vs. 100% of HOPE-K. Clinical outcomes support our hypothesis of machine perfusion being a safe and effective system to reduce ischemic preservation injuries in KT and in LT.
Identifiants
pubmed: 32269237
doi: 10.1038/s41598-020-62979-9
pii: 10.1038/s41598-020-62979-9
pmc: PMC7142134
doi:
Substances chimiques
Aspartate Aminotransferases
EC 2.6.1.1
Types de publication
Controlled Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6063Commentaires et corrections
Type : ErratumIn
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