Selective EP2 and Cox-2 inhibition suppresses cell migration by reversing epithelial-to-mesenchymal transition and Cox-2 overexpression and E-cadherin downregulation are implicated in neck metastasis of hypopharyngeal cancer.

Cyclooxygenase-2 E-cadherin EP2 epithelial-to-mesenchymal transition hypopharyngeal squamous cell carcinoma neck metastasis

Journal

American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030

Informations de publication

Date de publication:
2020
Historique:
received: 14 11 2019
accepted: 01 03 2020
entrez: 10 4 2020
pubmed: 10 4 2020
medline: 10 4 2020
Statut: epublish

Résumé

Cyclooxygenase-2 (Cox-2) has been shown to promote cancer initiation and progression through pleiotropic functions including induction of epithelial-to-mesenchymal transition (EMT) via its predominant product prostaglandin E

Identifiants

pubmed: 32269737
pmc: PMC7137058

Types de publication

Journal Article

Langues

eng

Pagination

1096-1113

Informations de copyright

AJTR Copyright © 2020.

Déclaration de conflit d'intérêts

None.

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Auteurs

Yoshihiro Watanabe (Y)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.
Department of Otorhinolaryngology, Tokyo Saiseikai Central Hospital Tokyo, Japan.

Yorihisa Imanishi (Y)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.
Department of Otorhinolaryngology-Head and Neck Surgery, Kawasaki Municipal Kawasaki Hospital Kawasaki, Japan.

Hiroyuki Ozawa (H)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.

Koji Sakamoto (K)

Department of Otorhinolaryngology-Head and Neck Surgery, Saiseikai Utsunomiya Hospital Utsunomiya, Japan.

Ryoichi Fujii (R)

Department of Otorhinolaryngology, Saiseikai Yokohamashi Tobu Hospital Yokohama, Japan.

Seiji Shigetomi (S)

Department of Otorhinolaryngology, Yokohama Municipal Citizen's Hospital Yokohama, Japan.

Noboru Habu (N)

Department of Otorhinolaryngology, Kyosai Tachikawa Hospital Tokyo, Japan.

Kuninori Otsuka (K)

Department of Otorhinolaryngology, Shin-Yurigaoka General Hospital Kawasaki, Japan.

Yoichiro Sato (Y)

Department of Otorhinolaryngology-Head and Neck Surgery, Kawasaki Municipal Kawasaki Hospital Kawasaki, Japan.

Mariko Sekimizu (M)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.

Fumihiro Ito (F)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.

Yuichi Ikari (Y)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.

Shin Saito (S)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.

Kaori Kameyama (K)

Department of Pathology, Keio University School of Medicine Tokyo, Japan.

Kaoru Ogawa (K)

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine Tokyo, Japan.

Classifications MeSH