Bilateral Breast Metastases from Epstein-Barr Virus-Associated Gastric Cancer during Pregnancy: Is There a Method to Its Madness?
Epstein-Barr virus
Gastric cancer
Neoplasm metastasis
Pregnancy
Tumor-infiltrating lymphocytes
Journal
Journal of gastric cancer
ISSN: 2093-582X
Titre abrégé: J Gastric Cancer
Pays: Korea (South)
ID NLM: 101559430
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
29
05
2019
revised:
27
07
2019
accepted:
24
08
2019
entrez:
10
4
2020
pubmed:
10
4
2020
medline:
10
4
2020
Statut:
ppublish
Résumé
Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%-2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (<0.1%), and this event is even rarer during pregnancy. Herein, we describe a 39-year-old Caucasian woman with a history of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) that was characterized by prominent tumor infiltrating lymphocytes. Three years after undergoing radical surgery, the patient developed bilateral breast nodules during her pregnancy. A breast biopsy was performed, and histology confirmed a diagnosis of EBVaGC; tumor cells showed positivity for cytokeratin 8/18 and E-cadherin, and negativity for cytokeratin 7, cytokeratin 20, cytokeratin 5/6, caudal type homebox 2, androgen receptor, mammaglobin, gross cystic disease fluid protein-15, and estrogen and progesterone receptors. We also discuss the main diagnostic pitfalls. To our knowledge, this is the first report of an EBVaGC with lymphoid stroma that developed breast metastases during pregnancy.
Identifiants
pubmed: 32269849
doi: 10.5230/jgc.2020.20.e1
pmc: PMC7105417
doi:
Types de publication
Case Reports
Langues
eng
Pagination
106-114Informations de copyright
Copyright © 2020. Korean Gastric Cancer Association.
Déclaration de conflit d'intérêts
Conflict of Interest: No potential conflict of interest relevant to this article was reported.
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