Cardio-respiratory, oxidative stress and acute mountain sickness responses to normobaric and hypobaric hypoxia in prematurely born adults.
Altitude Sickness
/ physiopathology
Biomarkers
/ blood
Blood Flow Velocity
/ physiology
Blood Pressure
/ physiology
Catalase
/ blood
Glutathione Peroxidase
/ blood
Heart Rate
/ physiology
Humans
Hypoxia
/ blood
Infant, Premature
Male
Malondialdehyde
/ blood
Middle Cerebral Artery
/ physiology
Oxidative Stress
/ physiology
Pressure
Registries
Young Adult
Acute mountain sickness
Cardio-respiratory responses
High altitude
Hypoxemia
Oxidative stress
Prematurity
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
06
03
2020
accepted:
04
04
2020
pubmed:
10
4
2020
medline:
18
3
2021
entrez:
10
4
2020
Statut:
ppublish
Résumé
We compared the effects of hypobaric and normobaric hypoxia on select cardio-respiratory responses, oxidative stress and acute mountain sickness (AMS) severity in prematurely born individuals, known to exhibit blunted hypoxic ventilatory response. Sixteen prematurely born but otherwise healthy males underwent two 8-h hypoxic exposures under: (1) hypobaric hypoxic [HH; terrestrial altitude 3840 m; P HH resulted in significantly lower resting (P = 0.010) and exercise (P = 0.004) SpO These data suggest that, in prematurely born adults, 8-h exposure to hypobaric, as opposed to normobaric hypoxia, provokes greater reductions in systemic oxygenation and antioxidant capacity. Further studies investigating prolonged hypobaric exposures in this population are warranted. NCT02780908 (ClinicalTrials.gov).
Identifiants
pubmed: 32270264
doi: 10.1007/s00421-020-04366-w
pii: 10.1007/s00421-020-04366-w
doi:
Substances chimiques
Biomarkers
0
Malondialdehyde
4Y8F71G49Q
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Banques de données
ClinicalTrials.gov
['NCT02780908']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1341-1355Subventions
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J3-7536
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