The hazard ratio as a measure of effect in clinical trials of elderly populations: common pitfalls and misconceptions.
Clinical trials
Elderly
Hazard ratio
Risk ratio
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
02
2020
accepted:
20
03
2020
pubmed:
10
4
2020
medline:
12
3
2021
entrez:
10
4
2020
Statut:
ppublish
Résumé
The hazard ratio is a measure of effect which is of paramount importance in etiological research, that is in studies aimed at assessing the strength of the causal relationship between a given treatment/exposure and a certain outcome. Despite the widespread use of the hazard ratio as a measure of effect in scientific reports and articles, the interpretation of this index is often accompanied by some misconceptions which can jeopardize the critical appraisal of randomized clinical trials (RCTs) and observational studies as well. Herein, using a series of examples derived from RCTs in the elderly subjects, we address major pitfalls regarding the interpretation of the hazard ratio in geriatric research.
Identifiants
pubmed: 32270409
doi: 10.1007/s40520-020-01538-8
pii: 10.1007/s40520-020-01538-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
505-511Références
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