Collagenated heterologous cortico-cancelleus bone mix stimulated dental pulp derived stem cells.
bone
dental pulp
gene expression
osteoblast differentiation
stem cells
Journal
Journal of biological regulators and homeostatic agents
ISSN: 0393-974X
Titre abrégé: J Biol Regul Homeost Agents
Pays: Italy
ID NLM: 8809253
Informations de publication
Date de publication:
Historique:
entrez:
10
4
2020
pubmed:
10
4
2020
medline:
27
6
2020
Statut:
ppublish
Résumé
Collagenated heretologous cortico-cancelleus bone mix (CHCCBM) is largely employed in maxillary and dental surgery for regeneration procedures, and is similar to human bone from chemical and physical point of view and promotes osteogenesis. In order to get more inside how this biomaterial induces osteoblast gene expression to promote bone formation, the mRNA levels of bone related genes were compared in human osteoblasts and dental pulp stem cells, using real time RT-PCR. The obtained results demonstrated that CHCCBM enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes SP7, FOSL1 and SPP1.
Substances chimiques
Proto-Oncogene Proteins c-fos
0
RNA, Messenger
0
SPP1 protein, human
0
Sp7 Transcription Factor
0
SP7 protein, human
0
fos-related antigen 1
0
Osteopontin
106441-73-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-5. DENTAL SUPPLEMENTInformations de copyright
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