Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
GPX5
PIWI-interacting RNA
epididymis
oxidative stress
piRNA
small noncoding RNA
Journal
Asian journal of andrology
ISSN: 1745-7262
Titre abrégé: Asian J Androl
Pays: China
ID NLM: 100942132
Informations de publication
Date de publication:
Historique:
pubmed:
10
4
2020
medline:
23
9
2021
entrez:
10
4
2020
Statut:
ppublish
Résumé
The mammalian epididymis not only plays a fundamental role in the maturation of spermatozoa, but also provides protection against various stressors. The foremost among these is the threat posed by oxidative stress, which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids, proteins, and nucleic acids. In mice, the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5 (GPX5) as a major luminal scavenger in the proximal caput epididymidal segment. Accordingly, the loss of GPX5-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx5
Identifiants
pubmed: 32270769
pii: 282086
doi: 10.4103/aja.aja_3_20
pmc: PMC7705982
doi:
Substances chimiques
RNA, Small Interfering
0
Glutathione Peroxidase
EC 1.11.1.9
selenium-independent glutathione peroxidase
EC 1.11.1.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
590-601Déclaration de conflit d'intérêts
None
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