Genome-wide association study identifies an early onset pancreatic cancer risk locus.
Carcinoma, Pancreatic Ductal
/ genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
/ genetics
Genome-Wide Association Study
/ methods
Humans
Male
Middle Aged
Pancreas
/ pathology
Pancreatic Neoplasms
/ genetics
Polymorphism, Single Nucleotide
/ genetics
Risk Factors
Pancreatic Neoplasms
early onset
genome-wide association study
pancreatic cancer
single nucleotide polymorphisms
very early onset pancreatic cancer
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
received:
18
07
2019
revised:
03
03
2020
accepted:
11
03
2020
pubmed:
10
4
2020
medline:
13
4
2021
entrez:
10
4
2020
Statut:
ppublish
Résumé
Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome-wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset ≤60 years, of whom 198 with age of onset ≤50, and 3227 controls from PanScan I-II, we observed four SNPs (rs7155613, rs2328991, rs4891017 and rs12610094) showing an association with EOPC risk (P < 1 × 10
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2065-2074Informations de copyright
© 2020 UICC.
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