Birth during the moderate weather seasons is associated with early onset of type 1 diabetes in the Mediterranean area.
birth season
early onset
type 1 diabetes mellitus
Journal
Diabetes/metabolism research and reviews
ISSN: 1520-7560
Titre abrégé: Diabetes Metab Res Rev
Pays: England
ID NLM: 100883450
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
revised:
13
03
2020
received:
27
09
2018
accepted:
18
03
2020
medline:
10
4
2020
pubmed:
10
4
2020
entrez:
10
4
2020
Statut:
ppublish
Résumé
To assess the association of seasonal and perinatal parameters with early age of type 1 diabetes (T1D) onset. A cross-sectional review of all medical records of T1D patients born between the years 1990 and 2005, and diagnosed before/by the age of 10 years, from 13 university-affiliated paediatric medical centres in Israel, was performed. Data included: gender, ethnicity, seasons of birth and disease onset, birth gestational age and weight, and autoimmune diseases of the probands and their first-degree family members. Statistical analysis included the Chi-square test or Mann-Whitney test, as appropriate and multivariate regression analysis. Enrolled were 1571 T1D patients at a median age of T1D onset 6.9 years (IQR 4.4,8.4); 336 of them presented before 4 years of age. The median age of this group was 2.5 years (IQR 1.7,3.2), and of the 1235 patients who presented after 4 years of age, median presentation age was 7.5 years (IQR 6.1,8.8). Multivariate regression analysis demonstrated that a more recent birth year; OR = 1.06, 95% CI 1.02-1.1, P = 0.003, and birth during the moderate weather months (September, October, March, and April) were significantly associated with younger age at T1D onset; OR = 1.68, 95% CI 1.17-2.4, P = 0.005. Our novel finding demonstrates the association between younger than 4 years old age at presentation and birth during moderate weather months. The results also support previous reports, that there is a slight increase in the annual incidence of T1D in the youngest age groups.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3318Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Ziegler AG, Pflueger M, Winkler C, et al. Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. J Autoimmun. 2011;37(1):3-7.
Koton S, IIRSG. Incidence of type 1 diabetes mellitus in the 0- to 17-yr-old Israel population, 1997-2003. Pediatr Diabetes. 2007;8(2):60-66.
Blumenfeld O, Dichtiar R, Shohat T, Israel IRSG. Trends in the incidence of type 1 diabetes among Jews and Arabs in Israel. Pediatr Diabetes. 2014;15(6):422-427.
Israeli Center for Disease Control (ICfDC). Israel Juvenile Diabetes Registry Report 2015. Jerusalem, Israel: Ministry of Health (Israel); 2017.
Egro FM. Why is type 1 diabetes increasing? J Mol Endocrinol. 2013;51(1):R1-R13.
Adlercreutz EH, Wingren CJ, Vincente RP, Merlo J, Agardh D. Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. Acta Paediatr. 2015;104(2):178-184.
Xia Y, Xie Z, Huang G, Zhou Z. Incidence and trend of type 1 diabetes and the underlying environmental determinants. Diabetes Metab Res Rev. 2019;35(1):e3075.
Petrone A, Bugawan TL, Mesturino CA, et al. The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region). Tissue Antigens. 2001;58(6):385-394.
Kuchlbauer V, Vogel M, Gausche R, et al. High birth weights but not excessive weight gain prior to manifestation are related to earlier onset of diabetes in childhood: ‘accelerator hypothesis’ revisited. Pediatr Diabetes. 2014;15(6):428-435.
Jones ME, Swerdlow AJ, Gill LE, Goldacre MJ. Pre-natal and early life risk factors for childhood onset diabetes mellitus: a record linkage study. Int J Epidemiol. 1998;27(3):444-449.
Steck AK, Johnson K, Barriga KJ, et al. Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care. 2011;34(6):1397-1399.
Urakami T, Suzuki J, Yoshida A, et al. Pathogenic characteristics at diagnosis in young children with type 1 diabetes presenting prior to 5 years of age. Clin Pediatr Endocrinol. 2008;17(4):113-119.
Wadsworth EJ, Shield JP, Hunt LP, Baum JD. A case-control study of environmental factors associated with diabetes in the under 5s. Diabet Med. 1997;14(5):390-396.
Dahlquist G, Källén B. Maternal-child blood group incompatibility and other perinatal events increase the risk for early-onset type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1992;35(7):671-675.
Lee HY, Lu CL, Chen HF, Su HF, Li CY. Perinatal and childhood risk factors for early-onset type 1 diabetes: a population-based case-control study in Taiwan. Eur J Public Health. 2015;25(6):1024-1029.
Dahlquist G, Savilahti E, Landin-Olsson M. An increased level of antibodies to beta-lactoglobulin is a risk determinant for early-onset type 1 (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk. Diabetologia. 1992;35(10):980-984.
de Goffau MC, Fuentes S, van den Bogert B, et al. Aberrant gut microbiota composition at the onset of type 1 diabetes in young children. Diabetologia. 2014;57(8):1569-1577.
Malmqvist E, Larsson HE, Jönsson I, et al. Maternal exposure to air pollution and type 1 diabetes-accounting for genetic factors. Environ Res. 2015;140:268-274.
Zheng P, Li Z, Zhou Z. Gut microbiome in type 1 diabetes: a comprehensive review. Diabetes Metab Res Rev. 2018;34(7):e3043.
Minikel EV, Zerr I, Collins SJ, et al. Ascertainment bias causes false signal of anticipation in genetic prion disease. Am J Hum Genet. 2014;95(4):371-382.
Kalliora MI, Vazeou A, Delis D, Bozas E, Thymelli I, Bartsocas CS. Seasonal variation of type 1 diabetes mellitus diagnosis in Greek children. Hormones (Athens). 2011;10(1):67-71.
Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379(9832):2162-2172.
Dobbins TA, Sullivan EA, Roberts CL, Simpson JM. Australian national birthweight percentiles by sex and gestational age, 1998-2007. Med J Aust. 2012;197(5):291-294.
MacGillivray DM, Kollmann TR. The role of environmental factors in modulating immune responses in early life. Front Immunol. 2014;5:434.
Mendes A, Aelenei D, Papoila AL, et al. Environmental and ventilation assessment in child day care Centers in Porto: the ENVIRH project. J Toxicol Environ Health A. 2014;77(14-16):931-943.
Lind T, Ekebom A, Alm Kübler K, Östensson P, Bellander T, Lõhmus M. Pollen season trends (1973-2013) in Stockholm area, Sweden. PLoS One. 2016;11(11):e0166887.
Kemppainen KM, Ardissone AN, Davis-Richardson AG, et al. Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care. 2015;38(2):329-332.
Walker WA. Initial intestinal colonization in the human infant and immune homeostasis. Ann Nutr Metab. 2013;63(Suppl 2):8-15.
Fouhy F, Watkins C, Hill CJ, et al. Perinatal factors affect the gut microbiota up to four years after birth. Nat Commun. 2019;10(1):1517.
Brown CT, Davis-Richardson AG, Giongo A, et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One. 2011;6(10):e25792.
Mika M, Mack I, Korten I, et al. Dynamics of the nasal microbiota in infancy: a prospective cohort study. J Allergy Clin Immunol. 2015;135(4):905-912.e911.
Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y. Seasonal variation in human gut microbiome composition. PLoS One. 2014;9(3):e90731.
Hassoun A, Huff MD, Weisman D, et al. Seasonal variation of respiratory pathogen colonization in asymptomatic health care professionals: a single-center, cross-sectional, 2-season observational study. Am J Infect Control. 2015;43(8):865-870.
Wang Z, Lv H, Zhu W, et al. Epidemiologic features of enterovirus 71-associated hand-foot-and-mouth disease from 2009 to 2013 in Zhejiang, China. Int J Environ Res Public Health. 2016;14(1):33-42.
Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014;9:1101-1110.
Shoshan A, Sella T, Shohat T, Goren I, Shalev V, Chodick G. A case-crossover study of infectious diseases and new diagnosis of type 1 diabetes. Pediatr Diabetes. 2012;13(7):583-586.
Karvonen M, Pitkäniemi J, Tuomilehto J. The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group. Diabetes Care. 1999;22(7):1066-1070.
El-Ziny MA, Salem NA, El-Hawary AK, Chalaby NM, Elsharkawy AA. Epidemiology of childhood type 1 diabetes mellitus in Nile Delta, northern Egypt-a retrospective study. J Clin Res Pediatr Endocrinol. 2014;6(1):9-15.
López-de-Andrés A, Jiménez-García R, Hernández-Barrera V, Isabel Jiménez-Trujillo M, Gil-de-Miguel A, Carrasco-Garrido P. Trends in hospitalizations among children with type 1 diabetes in Spain, 2001-2009. J Pediatr Endocrinol Metab. 2013;26(1-2):85-89.
Algert CS, McElduff A, Morris JM, Roberts CL. Perinatal risk factors for early onset of type 1 diabetes in a 2000-2005 birth cohort. Diabet Med. 2009;26(12):1193-1197.
D'Angeli MA, Merzon E, Valbuena LF, Tirschwell D, Paris CA, Mueller BA. Environmental factors associated with childhood-onset type 1 diabetes mellitus: an exploration of the hygiene and overload hypotheses. Arch Pediatr Adolesc Med. 2010;164(8):732-738.