Global REACH 2018: Andean highlanders, chronic mountain sickness and the integrative regulation of resting blood pressure.
Adult
Altitude Sickness
/ physiopathology
Arterial Pressure
/ physiology
Baroreflex
/ physiology
Blood Pressure
/ physiology
Blood Volume
/ physiology
Chronic Disease
Hemodynamics
/ physiology
Humans
Hypoxia
/ physiopathology
Male
Middle Aged
Muscle, Skeletal
/ physiology
Musculoskeletal Physiological Phenomena
Sympathetic Nervous System
/ physiopathology
Young Adult
arterial baroreflex
blood pressure control
chronic mountain sickness
excessive erythrocytosis
muscle sympathetic nerve activity
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
14
02
2020
accepted:
06
04
2020
pubmed:
10
4
2020
medline:
22
2
2022
entrez:
10
4
2020
Statut:
ppublish
Résumé
What is the central question of this study? Does chronic mountain sickness (CMS) alter sympathetic neural control and arterial baroreflex regulation of blood pressure in Andean (Quechua) highlanders? What is the main finding and its importance? Compared to healthy Andean highlanders, basal sympathetic vasomotor outflow is lower, baroreflex control of muscle sympathetic nerve activity is similar, supine heart rate is lower and cardiovagal baroreflex gain is greater in mild CMS. Taken together, these findings reflect flexibility in integrative regulation of blood pressure that may be important when blood viscosity and blood volume are elevated in CMS. The high-altitude maladaptation syndrome chronic mountain sickness (CMS) is characterized by excessive erythrocytosis and frequently accompanied by accentuated arterial hypoxaemia. Whether altered autonomic cardiovascular regulation is apparent in CMS is unclear. Therefore, during the 2018 Global REACH expedition to Cerro de Pasco, Peru (4383 m), we assessed integrative control of blood pressure (BP) and determined basal sympathetic vasomotor outflow and arterial baroreflex function in eight Andean natives with CMS ([Hb] 22.6 ± 0.9 g·dL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-116Informations de copyright
© 2020 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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