Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference.

Edges Epileptic network Epileptogenesis Ictogenesis Nodes Seizure control

Journal

Seizure
ISSN: 1532-2688
Titre abrégé: Seizure
Pays: England
ID NLM: 9306979

Informations de publication

Date de publication:
May 2020
Historique:
received: 31 01 2020
revised: 13 03 2020
accepted: 15 03 2020
pubmed: 10 4 2020
medline: 27 2 2021
entrez: 10 4 2020
Statut: ppublish

Résumé

Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.

Identifiants

pubmed: 32272333
pii: S1059-1311(20)30085-6
doi: 10.1016/j.seizure.2020.03.010
pmc: PMC7952007
mid: NIHMS1673775
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

78-85

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS109062
Pays : United States

Informations de copyright

Copyright © 2020 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest HZ has a grant award from the NIH (USA) on network analysis for epilepsy surgery, and is named as an inventor on patents for monitoring and modulating human brain activity.

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Auteurs

Hitten P Zaveri (HP)

Department of Neurology, Yale University, New Haven, CT 06520, USA.

Björn Schelter (B)

Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen AB24 3UE, UK.

Catherine A Schevon (CA)

Department of Neurology, Columbia University, New York, NY, USA.

Premysl Jiruska (P)

Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.

John G R Jefferys (JGR)

Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.

Gregory Worrell (G)

Mayo Systems Electrophysiology Laboratory, Departments of Neurology and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Andreas Schulze-Bonhage (A)

Epilepsy Center, University Medical Center Freiburg, Freiburg, Germany.

Rasesh B Joshi (RB)

Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Viktor Jirsa (V)

Institut de Neurosciences des Systèmes, Aix Marseille University, Marseille, France.

Marc Goodfellow (M)

Living Systems Institute, University of Exeter, Exeter, UK; Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Exeter, Exeter, UK; EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK.

Christian Meisel (C)

Department of Neurology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA; Department of Neurology, University Clinic Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.

Klaus Lehnertz (K)

Department of Epileptology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany; Interdisciplinary Center for Complex Systems, University of Bonn, Brühler Str. 7, 53175 Bonn, Germany. Electronic address: Klaus.Lehnertz@ukbonn.de.

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