Preconception resveratrol intake against infertility: Friend or foe?

aging assisted reproductive technology infertility resveratrol sirtuin

Journal

Reproductive medicine and biology

ISSN: 1445-5781

Titre abrégé: Reprod Med Biol

Pays: Japan

ID NLM: 101213278

Informations de publication

Date de publication:
Apr 2020

Historique:

received: 09 09 2019

revised: 20 09 2019

accepted: 25 09 2019

entrez: 11 4 2020

pubmed: 11 4 2020

medline: 11 4 2020

Statut: epublish

Résumé

Resveratrol is an antiaging, antioxidant, anti-inflammatory, and insulin-sensitizing natural polyphenolic compound. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian function, polycystic ovary syndrome (PCOS), or endometriosis. However, only one clinical trial in women undergoing in vitro fertilization (IVF) cycles using resveratrol has ever been reported. This review focuses on the potential therapeutic effects of resveratrol on pregnancy and on its advantages and disadvantages in pregnancy outcomes during infertility treatment. We performed a literature review to describe the known impacts of resveratrol on the ovary and endometrium. Resveratrol upregulates sirtuin (SIRT)1 expression in ovaries, which is associated with protection against oxidative stress. It leads to the activation of telomerase activity and mitochondrial function, improving ovarian function. In the endometrium, resveratrol downregulates the CRABP2-RAR pathway leading to suppressing decidual and senescent changes of endometrial cells, which is essential for embryo implantation and placentation. Moreover, resveratrol may also induce deacetylation of important decidual-related genes. Resveratrol has potential therapeutic effects for improving ovarian function; however, it also has anti-deciduogenic actions in uterine endometrium. In addition, its teratogenicity has not yet been ruled out; thus, resveratrol should be avoided during the luteal phase and pregnancy.

Sections du résumé

BACKGROUND BACKGROUND

METHODS METHODS

We performed a literature review to describe the known impacts of resveratrol on the ovary and endometrium.

RESULTS RESULTS

Resveratrol upregulates sirtuin (SIRT)1 expression in ovaries, which is associated with protection against oxidative stress. It leads to the activation of telomerase activity and mitochondrial function, improving ovarian function. In the endometrium, resveratrol downregulates the CRABP2-RAR pathway leading to suppressing decidual and senescent changes of endometrial cells, which is essential for embryo implantation and placentation. Moreover, resveratrol may also induce deacetylation of important decidual-related genes.

CONCLUSIONS CONCLUSIONS

Resveratrol has potential therapeutic effects for improving ovarian function; however, it also has anti-deciduogenic actions in uterine endometrium. In addition, its teratogenicity has not yet been ruled out; thus, resveratrol should be avoided during the luteal phase and pregnancy.

Identifiants

DOI: 10.1002/rmb2.12303 PMID: 32273814 PMC: PMC7138940

pubmed: 32273814

doi: 10.1002/rmb2.12303

pii: RMB212303

pmc: PMC7138940

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

107-113

Informations de copyright

Déclaration de conflit d'intérêts

All authors declare having no conflicts of interest.Human/Animal rights: This article does not contain any studies with human and animal subjects performed by any of the authors.

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