Physiological role of actin regulation in male fertility: Insight into actin capping proteins in spermatogenic cells.
CapZ actin capping protein
actin
actin cytoskeleton
male infertility
spermatogenesis
Journal
Reproductive medicine and biology
ISSN: 1445-5781
Titre abrégé: Reprod Med Biol
Pays: Japan
ID NLM: 101213278
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
12
11
2019
revised:
14
12
2019
accepted:
23
12
2019
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
11
4
2020
Statut:
epublish
Résumé
During spermatogenesis, cytoskeletal elements are essential for spermatogenic cells to change morphologically and translocate in the seminiferous tubule. Actin filaments have been revealed to be concentrated in specific regions of spermatogenic cells and are regulated by a large number of actin-binding proteins. Actin capping protein is one of the essential actin regulatory proteins, and a recent study showed that testis-specific actin capping protein may affect male infertility. The roles of actin during spermatogenesis and testis-specific actin capping protein were reviewed by referring to the previous literature. Actin filaments are involved in several crucial phases of spermatogenesis including acrosome biogenesis, flagellum formation, and nuclear processes such as the formation of synaptonemal complex. Besides, an implication for capacitation and acrosome reaction was also suggested. Testis-specific actin capping proteins are suggested to be associated with the removal of excess cytoplasm in mice. By the use of high-throughput sperm proteomics, lower protein expression of testis-specific actin capping protein in infertile men was also reported. Actin is involved in the crucial phases of spermatogenesis, and the altered expression of testis-specific actin capping proteins is suggested to be a cause of male infertility in humans.
Sections du résumé
BACKGROUND
BACKGROUND
During spermatogenesis, cytoskeletal elements are essential for spermatogenic cells to change morphologically and translocate in the seminiferous tubule. Actin filaments have been revealed to be concentrated in specific regions of spermatogenic cells and are regulated by a large number of actin-binding proteins. Actin capping protein is one of the essential actin regulatory proteins, and a recent study showed that testis-specific actin capping protein may affect male infertility.
METHODS
METHODS
The roles of actin during spermatogenesis and testis-specific actin capping protein were reviewed by referring to the previous literature.
MAIN FINDINGS RESULTS
UNASSIGNED
Actin filaments are involved in several crucial phases of spermatogenesis including acrosome biogenesis, flagellum formation, and nuclear processes such as the formation of synaptonemal complex. Besides, an implication for capacitation and acrosome reaction was also suggested. Testis-specific actin capping proteins are suggested to be associated with the removal of excess cytoplasm in mice. By the use of high-throughput sperm proteomics, lower protein expression of testis-specific actin capping protein in infertile men was also reported.
CONCLUSION
CONCLUSIONS
Actin is involved in the crucial phases of spermatogenesis, and the altered expression of testis-specific actin capping proteins is suggested to be a cause of male infertility in humans.
Identifiants
pubmed: 32273816
doi: 10.1002/rmb2.12316
pii: RMB212316
pmc: PMC7138945
doi:
Types de publication
Journal Article
Langues
eng
Pagination
120-127Informations de copyright
© 2020 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare no conflict of interest. Human and animal rights: This article does not contain any study with human and animal participants performed by any of the authors.
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