Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature.
Journal
Case reports in dentistry
ISSN: 2090-6447
Titre abrégé: Case Rep Dent
Pays: Egypt
ID NLM: 101573242
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
10
2019
accepted:
03
03
2020
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
11
4
2020
Statut:
epublish
Résumé
Ligneous periodontitis or destructive membranous periodontal disease is a rare condition involving gingival tissues, which is due to plasminogen deficiency and fibrin deposition. Plasminogen deficiency is an ultrarare autosomal recessive disease. The disease is characterized by gingival enlargement and periodontal tissue destruction that leads to rapid tooth loss despite treatment attempts. A defect in fibrinolysis and abnormal wound healing are the main pathogenesis of this condition. It is caused by mutations in Ligneous periodontitis has been rarely reported in India. The reasons could be because of the rarity of the disease or missed diagnosis. The need to take a proper history and perform a proper clinical examination and histopathologic evaluation has to be stressed when diagnosing and treating gingival enlargements. If a genetic condition is suspected, genetic screening is also needed. All these will help the clinician in correctly diagnosing the disease and formulating a proper treatment plan for managing the condition.
Sections du résumé
BACKGROUND
BACKGROUND
Ligneous periodontitis or destructive membranous periodontal disease is a rare condition involving gingival tissues, which is due to plasminogen deficiency and fibrin deposition. Plasminogen deficiency is an ultrarare autosomal recessive disease. The disease is characterized by gingival enlargement and periodontal tissue destruction that leads to rapid tooth loss despite treatment attempts. A defect in fibrinolysis and abnormal wound healing are the main pathogenesis of this condition. It is caused by mutations in
CONCLUSION
CONCLUSIONS
Ligneous periodontitis has been rarely reported in India. The reasons could be because of the rarity of the disease or missed diagnosis. The need to take a proper history and perform a proper clinical examination and histopathologic evaluation has to be stressed when diagnosing and treating gingival enlargements. If a genetic condition is suspected, genetic screening is also needed. All these will help the clinician in correctly diagnosing the disease and formulating a proper treatment plan for managing the condition.
Identifiants
pubmed: 32274221
doi: 10.1155/2020/5680535
pmc: PMC7136767
doi:
Types de publication
Case Reports
Langues
eng
Pagination
5680535Informations de copyright
Copyright © 2020 Arun Sadasivan et al.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Thromb Haemost. 1996 Dec;76(6):1004-8
pubmed: 8972025
Blood. 1999 May 15;93(10):3457-66
pubmed: 10233898
Thromb Haemost. 2001 Jun;85(6):1004-10
pubmed: 11434676
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Blood. 2018 Mar 22;131(12):1301-1310
pubmed: 29321155
J Dent Child (Chic). 2006 Sep-Dec;73(3):179-82
pubmed: 17367037
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Mar;91(3):334-7
pubmed: 11250632
Blood. 1997 Aug 1;90(3):958-66
pubmed: 9242524
Bioinformatics. 2010 Aug 15;26(16):2069-70
pubmed: 20562413
Int Ophthalmol. 1998-1999;22(4):201-6
pubmed: 10674863
Nucleic Acids Res. 2013 Jan;41(Database issue):D64-9
pubmed: 23155063
Am J Ophthalmol. 1989 Feb 15;107(2):160-6
pubmed: 2643880
J Biol Chem. 1990 Apr 15;265(11):6104-11
pubmed: 2318848
Blood. 1998 Mar 1;91(5):1616-24
pubmed: 9473227
J Oral Pathol Med. 1994 Oct;23(9):423-8
pubmed: 7823304
Curr Med Chem. 2008;15(9):923-9
pubmed: 18473800
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
Am J Pathol. 2011 Aug;179(2):819-28
pubmed: 21704601
Z Rechtsmed. 1988;101(2):99-104
pubmed: 3188675
Surv Ophthalmol. 2003 Jul-Aug;48(4):369-88
pubmed: 12850227
J Thromb Haemost. 2003 Nov;1(11):2397-403
pubmed: 14629475
Ophthalmology. 1987 Aug;94(8):949-59
pubmed: 3658371
J Thromb Haemost. 2007 Dec;5(12):2315-22
pubmed: 17900274
Blood. 2006 Nov 1;108(9):3021-6
pubmed: 16849641
Br Dent J. 2004 Oct 23;197(8):467-8
pubmed: 15547600
Thromb Haemost. 2005 Apr;93(4):647-54
pubmed: 15841308
Am J Dermatopathol. 2012 Feb;34(1):35-40
pubmed: 21993334
Cell Mol Life Sci. 2011 Mar;68(5):785-801
pubmed: 21136135
Haemophilia. 2008 Nov;14(6):1261-8
pubmed: 19141167
J Pediatr Ophthalmol Strabismus. 1986 May-Jun;23(3):137-40
pubmed: 3723296
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5899-904
pubmed: 8650190
N Engl J Med. 1998 Dec 3;339(23):1679-86
pubmed: 9834305
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
J Periodontol. 2012 Apr;83(4):465-76
pubmed: 21859319
J Periodontol. 1999 Aug;70(8):919-25
pubmed: 10476902
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan;107(1):77-80
pubmed: 18996031
J Periodontol. 2007 Jun;78(6):1164-75
pubmed: 17539733
BMC Oral Health. 2015 May 14;15:59
pubmed: 25971786