Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid.
Journal
Case reports in dermatological medicine
ISSN: 2090-6463
Titre abrégé: Case Rep Dermatol Med
Pays: United States
ID NLM: 101591808
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
12
2019
accepted:
04
03
2020
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
11
4
2020
Statut:
epublish
Résumé
Actinic reticuloid (AR)-a subtype of chronic actinic dermatitis-clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, histopathology, and phototesting were consistent with AR. The patient was treated with cyclosporine 150-300 mg/d. Under this therapy, he developed several times primary cutaneous anaplastic large cell lymphomas (C-ALCL) which in part tended to regress spontaneously under cyclosporine reduction. The association between cyclosporine treatment and development of C-ALCL and other CD30+ lymphoproliferative disorders has previously been reported in patients with atopic dermatitis, psoriasis, and transplant patients. In conclusion, the present case highlights the difficulties arising in the distinction between AR and CTCL and shows that long-term cyclosporine treatment may cause C-ALCL development in AR as well.
Identifiants
pubmed: 32274223
doi: 10.1155/2020/9435242
pmc: PMC7132347
doi:
Types de publication
Case Reports
Langues
eng
Pagination
9435242Informations de copyright
Copyright © 2020 T. Gambichler et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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