A Systematic Review of Prophylactic Anticoagulation in Nephrotic Syndrome.

anticoagulation arterial thromboembolism nephrotic syndrome prophylaxis venous thromboembolism

Journal

Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 17 10 2019
revised: 27 11 2019
accepted: 02 12 2019
entrez: 11 4 2020
pubmed: 11 4 2020
medline: 11 4 2020
Statut: epublish

Résumé

Nephrotic syndrome is associated with an increased risk of venous and arterial thromboembolism, which can be as high as 40% depending on the severity and underlying cause of nephrotic syndrome. The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend prophylactic anticoagulation only in idiopathic membranous nephropathy but acknowledge that existing data are limited and of low quality. There is a need for better identification of vulnerable patients in order to balance the risks of anticoagulation. We undertook a systematic search of the topic in MEDLINE, EMBASE and COCHRANE databases, for relevant articles between 1990 and 2019. A total of 2381 articles were screened, with 51 full-text articles reviewed. In all, 28 articles were included in the final review. We discuss the key questions of whom to anticoagulate, when to anticoagulate, and how to prophylactically anticoagulate adults with nephrotic syndrome. Using available evidence, we expand upon current KDIGO guidelines and construct a clinical algorithm to aid decision making for prophylactic anticoagulation in nephrotic syndrome.

Identifiants

pubmed: 32274450
doi: 10.1016/j.ekir.2019.12.001
pii: S2468-0249(19)31570-0
pmc: PMC7136344
doi:

Types de publication

Journal Article

Langues

eng

Pagination

435-447

Informations de copyright

© 2019 International Society of Nephrology. Published by Elsevier Inc.

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Auteurs

Raymond Lin (R)

Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.

Georgina McDonald (G)

Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.

Todd Jolly (T)

School of Medicine and Public Health, University of Newcastle, New South Wales, Australia.

Aidan Batten (A)

School of Medicine and Public Health, University of Newcastle, New South Wales, Australia.

Bobby Chacko (B)

Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.
School of Medicine and Public Health, University of Newcastle, New South Wales, Australia.

Classifications MeSH