A Systematic Review of Renal Functional Reserve in Adult Living Kidney Donors.
borderline kidney donors
glomerular filtration rate
kidney function
living kidney donation
nephron
renal functional reserve
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
29
06
2019
revised:
04
12
2019
accepted:
31
12
2019
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
11
4
2020
Statut:
epublish
Résumé
The kidney's capacity to increase its glomerular filtration rate (GFR) in response to a higher functional demand is known as the renal functional reserve (RFR). Good short-term outcomes after living kidney donation have led to more acceptance of borderline donors (with hypertension, obesity, older age) due the ongoing shortage of donor organs. Given recent concerns about increased long-term risk in some donor subgroups, better donor stratification is needed. Measurement of RFR could inform assessment of donor risk. A systematic literature review of studies that assessed RFR in donors pre- and/or post-donation was performed. Given study heterogeneity, descriptive analysis and narrative synthesis was conducted. Sixteen of 3250 identified studies published between 1956 and 2019 met inclusion criteria. Most studies were cross-sectional and conducted before ( Existing data suggest possible blunting of RFR post-donation in older, obese, and hypertensive donors, which may represent increased single-nephron GFR at baseline. The long-term implications of these changes deserve further study to determine utility in informing selection of borderline kidney donors.
Identifiants
pubmed: 32274451
doi: 10.1016/j.ekir.2019.12.021
pii: S2468-0249(20)30009-7
pmc: PMC7136324
doi:
Types de publication
Journal Article
Langues
eng
Pagination
448-458Informations de copyright
© 2020 International Society of Nephrology. Published by Elsevier Inc.
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