Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk.
Alzheimer’s
amyloid
expression quantitative trait loci
genome-wide association studies
microglia
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
11
4
2020
pubmed:
1
1
2019
medline:
1
1
2019
Statut:
ppublish
Résumé
Genome-wide association studies of late-onset Alzheimer's disease risk have previously identified genes primarily expressed in microglia that form a transcriptional network. Using transgenic mouse models of amyloid deposition, we previously showed that many of the mouse orthologues of these risk genes are co-expressed and associated with amyloid pathology. In this new study, we generate an improved RNA-seq-derived network that is expressed in amyloid-responsive mouse microglia and we statistically compare this with gene-level variation in previous human Alzheimer's disease genome-wide association studies to predict at least four new risk genes for the disease (
Identifiants
pubmed: 32274467
doi: 10.1093/braincomms/fcz022
pmc: PMC7145452
mid: EMS86151
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcz022Subventions
Organisme : Medical Research Council
ID : MR/L501542/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026004/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K01417X/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N008324/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom
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