RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel

Animals Aspergillus oryzae / enzymology Cattle Peptidyl-Prolyl Isomerase F / chemistry Drug Discovery Humans Mitochondria / metabolism Models, Molecular Protein Conformation Protein Refolding Ribonuclease T1 / chemistry

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
05 05 2020
Historique:
pubmed: 11 4 2020
medline: 22 12 2020
entrez: 11 4 2020
Statut: ppublish

Résumé

Human cyclophilin D is a mitochondrial peptidyl-prolyl isomerase that plays a role in regulating the opening of the mitochondrial permeability transition pore. It is considered a viable and promising molecular target for the treatment of diseases for which disease development is associated with pore opening, e.g., Alzheimer's disease or ischemia/reperfusion injury. Currently available and widely used

Identifiants

DOI: 10.1021/acs.biochem.9b01025 PMID: 32275395
pubmed: 32275395
doi: 10.1021/acs.biochem.9b01025
doi:

Substances chimiques

Peptidyl-Prolyl Isomerase F 0
Ribonuclease T1 EC 3.1.27.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1680-1687

Auteurs

Lucie Zemanova (L)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
ORCID: 0000-0002-2732-5935

Michaela Vaskova (M)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.

Monika Schmidt (M)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
ORCID: 0000-0003-4984-9155

Jana Roubalova (J)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.

Annamaria Haleckova (A)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.

Ondrej Benek (O)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.

Kamil Musilek (K)

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
University Hospital Hradec Kralove, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
ORCID: 0000-0002-7504-4062

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Aspergillus oryzae › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Pliage des protéines › Repliement des protéines › RNase T1 Refolding Assay for Determining...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Endoribonucleases › Ribonuclease T1 › RNase T1 Refolding Assay for Determining...