Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction.

Apoptosis Caspase 3 / chemistry Cell Line, Tumor Guanidine / chemistry Humans Infrared Rays Molecular Structure Nitro Compounds / chemistry Photochemical Processes Ultraviolet Rays

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
06 05 2020
Historique:
pubmed: 11 4 2020
medline: 14 4 2021
entrez: 11 4 2020
Statut: ppublish

Résumé

Caspase-3 (Casp-3) is an enzyme that efficiently induces apoptosis, a form of programmed cell death. We report a dendritic molecular glue

Identifiants

DOI: 10.1021/jacs.0c01823 PMID: 32275408
pubmed: 32275408
doi: 10.1021/jacs.0c01823
doi:

Substances chimiques

Nitro Compounds 0
CASP3 protein, human EC 3.4.22.-
Caspase 3 EC 3.4.22.-
Guanidine JU58VJ6Y3B

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8080-8084

Auteurs

Nina B Hentzen (NB)

Laboratorium für Organische Chemie, ETH Zürich, D-CHAB, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
ORCID: 0000-0003-1038-7424

Rina Mogaki (R)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0002-1045-7165

Saya Otake (S)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0001-7702-2193

Kou Okuro (K)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
ORCID: 0000-0003-0445-6358

Takuzo Aida (T)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Riken Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
ORCID: 0000-0002-0002-8017

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases effectrices › Caspase-3 › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Guanidine › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons infrarouges › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Composés chimiques organiques › Composés nitrés › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Phénomènes chimiques › Processus photochimiques › Intracellular Photoactivation of Caspase-3 by...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Intracellular Photoactivation of Caspase-3 by...