Are the processes of DNA replication and DNA repair reading a common structural chromatin unit?
Chromatin structure
DNA repair
DNA replication
DNA structure
chromatin function
high resolution microscopy
polymer modeling
Journal
Nucleus (Austin, Tex.)
ISSN: 1949-1042
Titre abrégé: Nucleus
Pays: United States
ID NLM: 101518322
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
1
1
2021
Statut:
ppublish
Résumé
Decades of investigation on genomic DNA have brought us deeper insights into its organization within the nucleus and its metabolic mechanisms. This was fueled by the parallel development of experimental techniques and has stimulated model building to simulate genome conformation in agreement with the experimental data. Here, we will discuss our recent discoveries on the chromatin units of DNA replication and DNA damage response. We will highlight their remarkable structural similarities and how both revealed themselves as clusters of nanofocal structures each on the hundred thousand base pair size range corresponding well with chromatin loop sizes. We propose that the function of these two global genomic processes is determined by the loop level organization of chromatin structure with structure dictating function.
Identifiants
pubmed: 32275847
doi: 10.1080/19491034.2020.1744415
pmc: PMC7289585
doi:
Substances chimiques
Chromatin
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-82Références
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