Selenium: Tracing Another Essential Element of Ferroptotic Cell Death.
PUFA
ferroptosis
ferroptosis suppressor protein 1
glutathione peroxidase 4
selenium
Journal
Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030
Informations de publication
Date de publication:
16 04 2020
16 04 2020
Historique:
received:
08
01
2020
revised:
02
03
2020
accepted:
17
03
2020
pubmed:
11
4
2020
medline:
13
5
2021
entrez:
11
4
2020
Statut:
ppublish
Résumé
The trace elements iron and selenium play decisive roles in a distinct form of necrotic cell death, known as ferroptosis. While iron promotes ferroptosis by contributing to Fenton-type reactions and uncontrolled lipid autoxidation, the hallmark of ferroptosis, selenium in the form of glutathione peroxidase 4 (GPX4), subdues phospholipid peroxidation and associated cell death. Beyond the canonical cystine/glutamate antiporter system x
Identifiants
pubmed: 32275866
pii: S2451-9456(20)30109-4
doi: 10.1016/j.chembiol.2020.03.012
pii:
doi:
Substances chimiques
S100 Calcium-Binding Protein A4
0
Selenoproteins
0
Sulfhydryl Compounds
0
Iron
E1UOL152H7
Phospholipid Hydroperoxide Glutathione Peroxidase
EC 1.11.1.12
Selenium
H6241UJ22B
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
409-419Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.