Roles of lncRNAs in cancer: Focusing on angiogenesis.

DNA Damage / genetics Drug Resistance, Neoplasm Genome, Human Humans Neoplasms / genetics Neovascularization, Pathologic / genetics RNA, Long Noncoding / genetics Tumor Microenvironment / genetics
Angiogenesis Cancer Long non-coding RNAs (lncRNAs) Metastasis Tumor microenvironment

Journal

Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521

Informations de publication

Date de publication:
01 Jul 2020
Historique:
received: 06 02 2020
revised: 31 03 2020
accepted: 05 04 2020
pubmed: 11 4 2020
medline: 2 6 2020
entrez: 11 4 2020
Statut: ppublish

Résumé

Approximately 98% of the human genome consists of non-coding sequences that are classified into two classes by size: small non-coding RNAs (≤200 nucleotides) and long non-coding RNAs (≥200 nucleotides). Long non-coding RNAs (lncRNAs) are involved in various cellular events and act as guides, signals, decoys, and dynamic scaffolds. Due to their oncogenic and tumor suppressive roles, lncRNAs are important in cancer development and growth. LncRNAs play their roles by modulating cancer hallmarks, including DNA damage, metastasis, immune escape, cell stemness, drug resistance, metabolic reprogramming, and angiogenesis. Angiogenesis is vital for solid tumors which guarantees their growth beyond 2 mm

Identifiants

DOI: 10.1016/j.lfs.2020.117647 PMID: 32275935
pubmed: 32275935
pii: S0024-3205(20)30395-7
doi: 10.1016/j.lfs.2020.117647
pii:
doi:

Substances chimiques

RNA, Long Noncoding 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

117647

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that there is no conflict of interest.

Auteurs

Ke-Tao Jin (KT)

Department of Colorectal Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing 312000, Zhejiang Province, PR China.

Jia-Yu Yao (JY)

Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China; Clinical Research Institute, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China.

Xing-Liang Fang (XL)

Acupuncture and Tuina Clinic, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China.

Hua Di (H)

Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China; Department of Hepatobiliary Surgery, Affiliated Hospital of Shaoxing University (Shaoxing Municipal Hospital), Shaoxing 312000, Zhejiang Province, PR China. Electronic address: 2019020045@hmc.edu.cn.

Ying-Yu Ma (YY)

Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China; Clinical Research Institute, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China. Electronic address: mayingyu@hmc.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › Tumeurs › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Roles of lncRNAs in cancer: Focusing on angiogenesis.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Roles of lncRNAs in cancer: Focusing on angiogenesis.