Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential.
bioactives
drug discovery
lung cancer
marine algae
mode of action
molecular target
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
08 Apr 2020
08 Apr 2020
Historique:
received:
29
02
2020
revised:
26
03
2020
accepted:
29
03
2020
entrez:
12
4
2020
pubmed:
12
4
2020
medline:
14
1
2021
Statut:
epublish
Résumé
Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of the conventional drugs. Recently, algae as source of high value-added compounds are considered as very promising source of these bioactive molecules. These are secondary metabolites that consist mainly of derivatives of peptides, carbohydrates, and lipids with various structures. Accordingly, various mechanisms by which different algae molecules demonstrate attenuation of tumor angiogenesis were stated and discussed. The mode of action of the algae bioactives is closely related to their nature and chemical structure. Furthermore, this literature review considers the synergistic effect between microalgae bioactives and conventional drugs and discuss the economic feasibility of producing microalgae bioactives at large scale to conclude with some future perspectives related to algae-based drug discovery.
Identifiants
pubmed: 32276401
pii: md18040197
doi: 10.3390/md18040197
pmc: PMC7230368
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Biological Products
0
Carbohydrates
0
Lipids
0
Peptides
0
Phytochemicals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Qatar National Research Fund
ID : NPRP8-1087-1-207
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