A comparative molecular analysis of DNA damage response, cell cycle progression, viability and apoptosis of malignant granulosa cells exposed to gemcitabine and cisplatin.
Antineoplastic Agents
/ metabolism
Apoptosis
/ drug effects
Cell Cycle
/ drug effects
Cell Line, Tumor
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cisplatin
/ metabolism
DNA Damage
/ drug effects
DNA Repair
/ physiology
Deoxycytidine
/ analogs & derivatives
Female
G2 Phase Cell Cycle Checkpoints
/ drug effects
Granulosa Cell Tumor
/ drug therapy
Granulosa Cells
/ drug effects
Humans
Gemcitabine
Anti-mullerian hormone
Apoptosis
COV434
Cisplatin
Estradiol
Gemcitabine
Granulosa cell tumor
KGN
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
16
02
2020
accepted:
03
04
2020
pubmed:
12
4
2020
medline:
17
2
2021
entrez:
12
4
2020
Statut:
ppublish
Résumé
We aimed to provide a comparative characterization of DNA damage response elements, survival/apoptosis and cell cycle progression of the malignant granulosa cells exposed to gemcitabine and cisplatin. Malignant granulosa tumor cell lines COV434 and KGN were used for the experiments. Cell viability, proliferation, DNA damage response and apoptosis were investigated. Cell cycle progression was assessed. In vitro estradiol (E
Identifiants
pubmed: 32277442
doi: 10.1007/s11033-020-05426-2
pii: 10.1007/s11033-020-05426-2
doi:
Substances chimiques
Antineoplastic Agents
0
Deoxycytidine
0W860991D6
Cisplatin
Q20Q21Q62J
Gemcitabine
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3789-3796Subventions
Organisme : Koc University Research Center for Translational Medicine
ID : -