Exosomal miRNAs in osteoarthritis.
Exosomes
Musculoskeletal disorder
Osteoarthritis
miRNA
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
14
02
2020
accepted:
06
04
2020
pubmed:
12
4
2020
medline:
17
2
2021
entrez:
12
4
2020
Statut:
ppublish
Résumé
Exosomes, as lipid nanostructure, are secreted by approximately all cell types within the body and actively involved in either short or long distances cell-cell communication in an autocrine and paracrine manner. Recently, exosomes are widely used as a nanocarrier for delivery of various nucleotide- or protein passed molecules including miRNA, and drugs into various cells, as a therapeutic strategy in a broad range of diseases including osteoarthritis. Osteoarthritis is one of the most common debilitating chronic musculoskeletal disorders with a multifaceted condition and an increasing impact on the quality of life. Therefore, this review aims to focus on the current knowledge of the exosomal miRNAs in the osteoarthritis to address their potential therapeutic application.
Identifiants
pubmed: 32277444
doi: 10.1007/s11033-020-05443-1
pii: 10.1007/s11033-020-05443-1
doi:
Substances chimiques
MicroRNAs
0
Exosome Multienzyme Ribonuclease Complex
EC 3.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4737-4748Références
Jahanban-Esfahlan R, Mehrzadi S, Reiter RJ, Seidi K, Majidinia M, Baghi HB, Khatami N, Yousefi B, Sadeghpour A (2018) Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes. Br J Pharmacol 175(16):3230–3238
pubmed: 28585236
doi: 10.1111/bph.13898
Man G, Mologhianu G (2014) Osteoarthritis pathogenesis—a complex process that involves the entire joint. J Med Life 7(1):37
pubmed: 24653755
pmcid: 3956093
Xia B, Chen D, Zhang J, Hu S, Jin H, Tong P (2014) Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int 95(6):495–505
pubmed: 25311420
pmcid: 4747051
doi: 10.1007/s00223-014-9917-9
Maruotti N, Corrado A, Cantatore FP (2017) Osteoblast role in osteoarthritis pathogenesis. J Cell Physiol 232(11):2957–2963
pubmed: 28425564
pmcid: 5575507
doi: 10.1002/jcp.25969
Gu Y-T, Chen J, Meng Z-L, Ge W-Y, Bian Y-Y, Cheng S-W, Xing C-K, Yao J-L, Fu J, Peng L (2017) Research progress on osteoarthritis treatment mechanisms. Biomed Pharmacother 93:1246–1252
pubmed: 28738541
doi: 10.1016/j.biopha.2017.07.034
Behera J, Tyagi N (2018) Exosomes: mediators of bone diseases, protection, and therapeutics potential. Oncoscience 5(5–6):181–195. https://doi.org/10.18632/oncoscience.421
doi: 10.18632/oncoscience.421
pubmed: 30035185
pmcid: 6049320
Glyn-Jones S, Palmer A, Agricola R, Price A, Vincent T, Weinans H, Carr A (2015) Osteoarthritis. The Lancet 386(9991):376–387
doi: 10.1016/S0140-6736(14)60802-3
Tofino-Vian M, Guillén MI, Alcaraz MJ (2018) Extracellular vesicles: a new therapeutic strategy for joint conditions. Biochem Pharmacol 153:134
pubmed: 29427625
doi: 10.1016/j.bcp.2018.02.004
Toh WS, Lai RC, Hui JHP, Lim SK (2017) MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment. In: Seminars in cell & developmental biology. Elsevier, pp 56–64
Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, Goldring SR, Jones G, Teichtahl AJ, Pelletier JP (2016) Osteoarthr Nat Rev Dis Primers 2:16072. https://doi.org/10.1038/nrdp.2016.72
doi: 10.1038/nrdp.2016.72
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier J-P, Fahmi H (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7(1):33
pubmed: 21119608
doi: 10.1038/nrrheum.2010.196
Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CT (2019) Intra-articular treatment options for knee osteoarthritis. Nat Rev Rheumatol 15(2):77–90
pubmed: 30498258
pmcid: 6390843
doi: 10.1038/s41584-018-0123-4
Jevsevar DS, Brown GA, Jones DL, Matzkin EG, Manner PA, Mooar P, Schousboe JT, Stovitz S, Sanders JO, Bozic KJ (2013) The American Academy of Orthopaedic Surgeons evidence-based guideline on: treatment of osteoarthritis of the knee. JBJS 95(20):1885–1886
doi: 10.2106/00004623-201310160-00010
Jüni P, Hari R, Rutjes AW, Fischer R, Silletta MG, Reichenbach S, da Costa BR (2015) Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev 10:CD005328
Bedard NA, Pugely AJ, Elkins JM, Duchman KR, Westermann RW, Liu SS, Gao Y, Callaghan JJ (2017) The John N. Insall award: do intraarticular injections increase the risk of infection after TKA? Clin Orthop Relat Res 475(1):45–52
pubmed: 26970991
doi: 10.1007/s11999-016-4757-8
Caborn D, Rush J, Lanzer W, Parenti D, Murray C (2004) A randomized, single-blind comparison of the efficacy and tolerability of hylan GF 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee. J Rheumatol 31(2):333–343
pubmed: 14760806
Wernecke C, Braun HJ, Dragoo JL (2015) The effect of intra-articular corticosteroids on articular cartilage: a systematic review. Orthop J Sports Med 3(5):2325967115581163
pubmed: 26674652
pmcid: 4622344
Malfait A, Tortorella M, Thompson J, Hills R, Meyer D, Jaffee B, Chinn K, Ghoreishi-Haack N, Markosyan S, Arner E (2009) Intra-articular injection of tumor necrosis factor-α in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation. Osteoarthrit Cartil 17(5):627–635
doi: 10.1016/j.joca.2008.10.005
Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J, Ding C (2010) Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthrit Cartil 18(11):1441–1447
doi: 10.1016/j.joca.2010.08.016
Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi K, Aoki Y, Nakamura J, Ishikawa T (2015) Efficacy of direct injection of etanercept into knee joints for pain in moderate and severe knee osteoarthritis. Yonsei Med J 56(5):1379–1383
pubmed: 26256983
pmcid: 4541670
doi: 10.3349/ymj.2015.56.5.1379
Rutjes AW, Jüni P, da Costa BR, Trelle S, Nüesch E, Reichenbach S (2012) Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med 157(3):180–191
pubmed: 22868835
doi: 10.7326/0003-4819-157-3-201208070-00473
Bowen JE (2015) Technical issues in harvesting and concentrating stem cells (bone marrow and adipose). PM&R 7(4):S8–S18
doi: 10.1016/j.pmrj.2015.01.025
Chahla J, Dean CS, Moatshe G, Pascual-Garrido C, Serra Cruz R, LaPrade RF (2016) Concentrated bone marrow aspirate for the treatment of chondral injuries and osteoarthritis of the knee: a systematic review of outcomes. Orthop J Sports Med 4(1):2325967115625481
pubmed: 26798765
pmcid: 4714134
doi: 10.1177/2325967115625481
Turner L, Knoepfler P (2016) Selling stem cells in the USA: assessing the direct-to-consumer industry. Cell Stem Cell 19(2):154–157
pubmed: 27374789
doi: 10.1016/j.stem.2016.06.007
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143–147
doi: 10.1126/science.284.5411.143
pubmed: 10102814
Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA (2009) Platelet-rich plasma: current concepts and application in sports medicine. JAAOS 17(10):602–608
pubmed: 19794217
Khoshbin A, Leroux T, Wasserstein D, Marks P, Theodoropoulos J, Ogilvie-Harris D, Gandhi R, Takhar K, Lum G, Chahal J (2013) The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Arthroscopy 29(12):2037–2048
pubmed: 24286802
doi: 10.1016/j.arthro.2013.09.006
Chahla J, Cinque ME, Piuzzi NS, Mannava S, Geeslin AG, Murray IR, Dornan GJ, Muschler GF, LaPrade RF (2017) A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature. JBJS 99(20):1769–1779
doi: 10.2106/JBJS.16.01374
Hsu WK, Mishra A, Rodeo SR, Fu F, Terry MA, Randelli P, Canale TS, Kelly FB (2013) Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment. JAAOS 21(12):739–748
pubmed: 24292930
Chen J-Q, Papp G, Szodoray P, Zeher M (2016) The role of microRNAs in the pathogenesis of autoimmune diseases. Autoimmun Rev 15(12):1171–1180
pubmed: 27639156
doi: 10.1016/j.autrev.2016.09.003
Majidinia M, Yousefi B (2016) DNA damage response regulation by microRNAs as a therapeutic target in cancer. DNA Repair 47:1–11
pubmed: 27697364
doi: 10.1016/j.dnarep.2016.09.003
Majidinia M, Darband SG, Kaviani M, Nabavi SM, Jahanban-Esfahlan R, Yousefi B (2018) Cross-regulation between Notch signaling pathway and miRNA machinery in cancer. DNA Repair 66–67:30–41
pubmed: 29723707
doi: 10.1016/j.dnarep.2018.04.002
Mihanfar A, Fattahi A, Nejabati HR (2017) MicroRNA-mediated drug resistance in ovarian cancer. J Cell Physiol 234:3180
pubmed: 28628227
doi: 10.1002/jcp.26060
Moein S, Vaghari-Tabari M, Qujeq D, Majidinia M, Nabavi SM, Yousefi B (2018) MiRNAs and inflammatory bowel disease: an interesting new story. J Cell Physiol 234:3277
pubmed: 30417350
doi: 10.1002/jcp.27173
Majidinia M, Mihanfar A, Rahbarghazi R, Nourazarian A, Bagca B, Avci ÇB (2016) The roles of non-coding RNAs in Parkinson’s disease. Mol Biol Rep 43(11):1193–1204
pubmed: 27492082
doi: 10.1007/s11033-016-4054-3
Bardell D, Peffers M, Clegg P, Molloy A, Goljanek-Whysall K (2018) The role of microRNAs in tendon dysfunction. Osteoarthr Cartil 26:S165–S166
doi: 10.1016/j.joca.2018.02.361
Cullen BR (2004) Transcription and processing of human microRNA precursors. Mol Cell 16(6):861–865
pubmed: 15610730
doi: 10.1016/j.molcel.2004.12.002
Cai X, Hagedorn CH, Cullen BR (2004) Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10(12):1957–1966
pubmed: 15525708
pmcid: 1370684
doi: 10.1261/rna.7135204
Fabian MR, Sonenberg N, Filipowicz W (2010) Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79:351–379
pubmed: 20533884
doi: 10.1146/annurev-biochem-060308-103103
Carthew RW, Sontheimer EJ (2009) Origins and mechanisms of miRNAs and siRNAs. Cell 136(4):642–655
pubmed: 19239886
pmcid: 2675692
doi: 10.1016/j.cell.2009.01.035
Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R (2006) Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20(5):515–524
pubmed: 16510870
doi: 10.1101/gad.1399806
Pillai RS, Bhattacharyya SN, Filipowicz W (2007) Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 17(3):118–126
pubmed: 17197185
doi: 10.1016/j.tcb.2006.12.007
Dai R, Ahmed SA (2011) MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res 157(4):163–179
pubmed: 21420027
pmcid: 3072681
doi: 10.1016/j.trsl.2011.01.007
Li N, Long B, Han W, Yuan S, Wang K (2017) microRNAs: important regulators of stem cells. Stem Cell Res Therapy 8(1):110
doi: 10.1186/s13287-017-0551-0
Garzon R, Croce CM (2008) MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol 15(4):352–358
pubmed: 18536574
doi: 10.1097/MOH.0b013e328303e15d
Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS (2010) MicroRNA regulation of neural stem cells and neurogenesis. J Neurosci 30(45):14931–14936
pubmed: 21068294
pmcid: 3071711
doi: 10.1523/JNEUROSCI.4280-10.2010
Callis TE, Chen J-F, Wang D-Z (2007) MicroRNAs in skeletal and cardiac muscle development. DNA Cell Biol 26(4):219–225
pubmed: 17465888
doi: 10.1089/dna.2006.0556
Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ (2005) The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci 102(31):10898–10903
pubmed: 16040801
doi: 10.1073/pnas.0504834102
pmcid: 1182454
Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM (2008) Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci 105(6):1949–1954
pubmed: 18238902
doi: 10.1073/pnas.0707900105
pmcid: 2538863
Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong M (2015) Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage. Osteoarthritis Cartil 23(7):1214–1220
doi: 10.1016/j.joca.2015.02.015
Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S (2010) MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev 24:1173
pubmed: 20466812
pmcid: 2878654
doi: 10.1101/gad.1915510
Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A (2012) The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum 64(6):1909–1919
pubmed: 22143896
doi: 10.1002/art.34314
Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z (2016) MicroRNA-455–3p modulates cartilage development and degeneration through modification of histone H3 acetylation. Biochim et Biophys Acta 12:2881–2891
doi: 10.1016/j.bbamcr.2016.09.010
Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W (2015) MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2. FEBS Lett 589(23):3671–3678
pubmed: 26474644
doi: 10.1016/j.febslet.2015.09.032
Sun H, Zhao X, Zhang C, Zhang Z, Lun J, Liao W, Zhang Z (2018) MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation. Cell Death Dis 9(5):1–13
Sondag GR, Haqqi TM (2016) The role of microRNAs and their targets in osteoarthritis. Curr Rheumatol Rep 18(8):56
pubmed: 27402113
pmcid: 5294969
doi: 10.1007/s11926-016-0604-x
Jones S, Watkins G, Le Good N, Roberts S, Murphy C, Brockbank S, Needham M, Read S, Newham P (2009) The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13. Osteoarthritis Cartil 17(4):464–472
doi: 10.1016/j.joca.2008.09.012
Li Z-C, Han N, Li X, Li G, Liu Y-Z, Sun G-X, Wang Y, Chen G-T, Li G-F (2015) Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis. Int J Clin Exp Pathol 8(3):2555
pubmed: 26045761
pmcid: 4440070
Santini P, Politi L, Dalla Vedova P, Scandurra R, d’Abusco AS (2014) The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis. Rheumatol Int 34(5):711–716
pubmed: 23595570
doi: 10.1007/s00296-013-2754-8
Makki MS, Haseeb A, Haqqi TM (2015) MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein–induced protein 1 expression in interleukin-1β–stimulated human chondrocytes. Arthritis Rheumatol 67(8):2117–2128
pubmed: 25917063
pmcid: 4519390
doi: 10.1002/art.39173
Makki MS, Haqqi TM (2015) miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes. Exp Mol Med 47(10):e189
pubmed: 26450708
pmcid: 4673474
doi: 10.1038/emm.2015.66
Akhtar N, Haqqi TM (2012) MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes. Ann Rheum Dis 71:1073
pubmed: 22294637
doi: 10.1136/annrheumdis-2011-200519
Park S, Cheon E, Kim H (2013) MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes. Osteoarthritis Cartil 21(7):981–989
doi: 10.1016/j.joca.2013.04.012
Kulkarni R, Patki P, Jog V, Gandage S, Patwardhan B (1991) Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 33(1–2):91–95
pubmed: 1943180
doi: 10.1016/0378-8741(91)90167-C
Grover AK, Samson SE (2015) Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. Nutr J 15(1):1
doi: 10.1186/s12937-015-0115-z
Kim J-H, Kim S-J (2014) Overexpression of microRNA-25 by withaferin A induces cyclooxygenase-2 expression in rabbit articular chondrocytes. J Pharmacol Sci 125(1):83–90
pubmed: 24748433
doi: 10.1254/jphs.13232FP
Tardif G, Hum D, Pelletier J-P, Duval N, Martel-Pelletier J (2009) Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord 10(1):148
pubmed: 19948051
pmcid: 2792220
doi: 10.1186/1471-2474-10-148
Akhtar N, Rasheed Z, Ramamurthy S, Anbazhagan AN, Voss FR, Haqqi TM (2010) MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum 62(5):1361–1371
pubmed: 20131257
pmcid: 3139404
doi: 10.1002/art.27329
Park SJ, Cheon EJ, Lee MH, Kim HA (2013) MicroRNA-127-5p Regulates matrix metalloproteinase 13 expression and interleukin-1β–induced catabolic effects in human chondrocytes. Arthritis Rheum 65(12):3141–3152
pubmed: 24022470
doi: 10.1002/art.38188
Vonk LA, Kragten AH, Dhert W, Saris DB, Creemers LB (2014) Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes. Osteoarthritis Cartil 22(1):145–153
doi: 10.1016/j.joca.2013.11.006
Meng F, Zhang Z, Chen W, Huang G, He A, Hou C, Long Y, Yang Z, Liao W (2016) MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses. Osteoarthritis Cartil 24(5):932–941
doi: 10.1016/j.joca.2015.12.012
Wang G, Zhang Y, Zhao X, Meng C, Ma L, Kong Y (2015) MicroRNA-411 inhibited matrix metalloproteinase 13 expression in human chondrocytes. Am J Transl Res 7(10):2000
pubmed: 26692943
pmcid: 4656776
Liang Z-j, Zhuang H, Wang G-x, Li Z, Zhang H-t, Yu T-q, Zhang B-d (2012) MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1β-stimulated human articular chondrocyte C28/I2 cells. Inflamm Res 61(5):503–509
pubmed: 22273691
doi: 10.1007/s00011-012-0438-6
Song J, Lee M, Kim D, Han J, Chun C-H, Jin E-J (2013) MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity. Biochem Biophys Res Commun 431(2):210–214
pubmed: 23313477
doi: 10.1016/j.bbrc.2012.12.133
Ji Q, Xu X, Xu Y, Fan Z, Kang L, Li L, Liang Y, Guo J, Hong T, Li Z (2016) miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage. J Mol Med 94(6):681–694
pubmed: 26816250
doi: 10.1007/s00109-016-1380-9
Zheng H, Chen C (2015) Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies. BMJ Open 5(12):e007568
pubmed: 26656979
pmcid: 4679914
doi: 10.1136/bmjopen-2014-007568
Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A (2008) Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS ONE 3(11):e3740
pubmed: 19011694
pmcid: 2582945
doi: 10.1371/journal.pone.0003740
Kostopoulou F, Malizos KN, Papathanasiou I, Tsezou A (2015) MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes. Arthritis Res Therapy 17(1):42
doi: 10.1186/s13075-015-0556-y
Xie Q, Wei M, Kang X, Liu D, Quan Y, Pan X, Liu X, Liao D, Liu J, Zhang B (2015) Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes. Biosci Rep 35:20150071
doi: 10.1042/BSR20150071
Abouheif MM, Nakasa T, Shibuya H, Niimoto T, Kongcharoensombat W, Ochi M (2010) Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro. Rheumatology 49(11):2054–2060
pubmed: 20675358
doi: 10.1093/rheumatology/keq247
Li J, Huang J, Dai L, Yu D, Chen Q, Zhang X, Dai K (2012) miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4. Arthritis Res Therapy 14(2):R75
doi: 10.1186/ar3798
Jin L, Zhao J, Jing W, Yan S, Wang X, Xiao C, Ma B (2014) Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro. Int J Mol Med 34(2):451–463
pubmed: 24939082
pmcid: 4094584
doi: 10.3892/ijmm.2014.1808
Bai R, Zhao A, Zhao Z, Liu W, Jian D (2015) MicroRNA-195 induced apoptosis in hypoxic chondrocytes by targeting hypoxia-inducible factor 1 alpha. Eur Rev Med Pharmacol Sci 19(4):545–551
pubmed: 25753868
Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, Shiau AL, Wu CL (2012) Brief Report: Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223. Arthritis Rheum 64(10):3240–3245
pubmed: 22674011
doi: 10.1002/art.34550
Kim D, Song J, Ahn C, Kang Y, Chun C-H, Jin E-J (2014) Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus. Bone 64:124–131
pubmed: 24727161
doi: 10.1016/j.bone.2014.04.001
Caramés B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M (2010) Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 62(3):791–801
pubmed: 20187128
pmcid: 2838960
doi: 10.1002/art.27305
Caramés B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M (2012) Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis 71(4):575–581
pubmed: 22084394
doi: 10.1136/annrheumdis-2011-200557
Bouderlique T, Vuppalapati KK, Newton PT, Li L, Barenius B, Chagin AS (2016) Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis. Ann Rheum Dis 75(3):627–631
pubmed: 26438374
doi: 10.1136/annrheumdis-2015-207742
Zhang F, Wang J, Chu J, Yang C, Xiao H, Zhao C, Sun Z, Gao X, Chen G, Han Z (2015) MicroRNA-146a induced by hypoxia promotes chondrocyte autophagy through Bcl-2. Cell Physiol Biochem 37(4):1442–1453
pubmed: 26492575
doi: 10.1159/000438513
D'Adamo S, Alvarez-Garcia O, Muramatsu Y, Flamigni F, Lotz MK (2016) MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins. Osteoarthritis Cartil 24(6):1082–1091
doi: 10.1016/j.joca.2016.01.005
Song J, Ahn C, Chun CH, Jin EJ (2014) A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis. J Orthop Res 32(12):1628–1635
pubmed: 25196583
doi: 10.1002/jor.22718
Zhao X, Wang T, Cai B, Wang X, Feng W, Han Y, Li D, Li S, Liu J (2019) MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. Am J Transl Res 11(4):2232
pubmed: 31105831
pmcid: 6511756
Yang D-W, Qian G-B, Jiang M-J, Wang P, Wang K-Z (2019) Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB signaling pathway by regulating CCL4 in osteoarthritis. Gene Ther 26(6):217–229
pubmed: 30940879
doi: 10.1038/s41434-019-0068-5
Zhong G, Long H, Ma S, Shunhan Y, Li J, Yao J (2019) miRNA-335-5p relieves chondrocyte inflammation by activating autophagy in osteoarthritis. Life Sci 226:164–172
pubmed: 30970265
doi: 10.1016/j.lfs.2019.03.071
Zhao X, Li H, Wang L (2019) MicroRNA-107 regulates autophagy and apoptosis of osteoarthritis chondrocytes by targeting TRAF3. Int Immunopharmacol 71:181–187
pubmed: 30909133
doi: 10.1016/j.intimp.2019.03.005
Lian W-S, Ko J-Y, Wu R-W, Sun Y-C, Chen Y-S, Wu S-L, Weng L-H, Jahr H, Wang F-S (2018) MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12. Cell Death Dis 9(9):1–14
doi: 10.1038/s41419-018-0994-y
Wang F-S, Lian W-S, Sun Y-C, Ko J-Y, Chen Y-S (2018) MicroRNA-128 impairs cartilage integrity and deteriorates osteoarthritis pathogenesis through deregulating chondrocyte autophagy. In: Arthritis & rheumatology. Wiley 111 River St, Hoboken 07030-5774, NJ, USA
Swingler T, Niu L, Smith P, Paddy P, Le L, Barter M, Young D, Clark I (2019) The function of microRNAs in cartilage and osteoarthritis. Clin Exp Rheumatol 37(5):40–47
pubmed: 31621575
Nazimek K, Bryniarski K, Santocki M, Ptak W (2015) Exosomes as mediators of intercellular communication: clinical implications. Pol Arch Med Wewn 125(5):370–380
pubmed: 25978300
Cobelli NJ, Leong DJ, Sun HB (2017) Exosomes: biology, therapeutic potential, and emerging role in musculoskeletal repair and regeneration. Ann N Y Acad Sci 1410(1):57–67
pubmed: 29125180
doi: 10.1111/nyas.13469
Théry C, Zitvogel L, Amigorena S (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2(8):569
pubmed: 12154376
doi: 10.1038/nri855
Simons M, Raposo G (2009) Exosomes–vesicular carriers for intercellular communication. Curr Opin Cell Biol 21(4):575–581
pubmed: 19442504
doi: 10.1016/j.ceb.2009.03.007
Mathivanan S, Ji H, Simpson RJ (2010) Exosomes: extracellular organelles important in intercellular communication. J Proteom 73(10):1907–1920
doi: 10.1016/j.jprot.2010.06.006
Isola L, Chen AS (2017) Exosomes: the messengers of health and disease. Curr Neuropharmacol 15(1):157–165
pubmed: 27568544
pmcid: 5327461
doi: 10.2174/1570159X14666160825160421
Latifi Z, Fattahi A, Ranjbaran A, Nejabati HR, Imakawa K (2018) Potential roles of metalloproteinases of endometrium-derived exosomes in embryo-maternal crosstalk during implantation. J Cell Physiol 233(6):4530–4545
pubmed: 29115666
doi: 10.1002/jcp.26259
Raje N, Roodman GD (2011) Advances in the biology and treatment of bone disease in multiple myeloma. Clin Cancer Res 17(6):1278–1286
pubmed: 21411443
doi: 10.1158/1078-0432.CCR-10-1804
Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, Lotz MK, Ochi M (2014) Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Therapy 16(4):R163
doi: 10.1186/ar4679
Kolhe R, Hunter M, Liu S, Jadeja RN, Pundkar C, Mondal AK, Mendhe B, Drewry M, Rojiani MV, Liu Y (2017) Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis. Sci Rep 7(1):2029
pubmed: 28515465
pmcid: 5435729
doi: 10.1038/s41598-017-01905-y
Domenis R, Zanutel R, Caponnetto F, Toffoletto B, Cifù A, Pistis C, Di Benedetto P, Causero A, Pozzi M, Bassini F (2017) Characterization of the proinflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis. Mediat Inflamm 2017:4814987
doi: 10.1155/2017/4814987
Han C, Sun X, Liu L, Jiang H, Shen Y, Xu X, Li J, Zhang G, Huang J, Lin Z (2016) Exosomes and their therapeutic potentials of stem cells. Stem Cells Int. https://doi.org/10.1155/2016/7653489
doi: 10.1155/2016/7653489
pubmed: 27994624
pmcid: 5138489
Linero I, Chaparro O (2014) Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration. PLoS ONE 9(9):e107001
pubmed: 25198551
pmcid: 4157844
doi: 10.1371/journal.pone.0107001
Jiang L, Vader P, Schiffelers R (2017) Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy. Gene Ther 24(3):157
pubmed: 28140387
doi: 10.1038/gt.2017.8
Darband SG, Mirza-Aghazadeh-Attari M, Kaviani M, Mihanfar A, Sadighparvar S, Yousefi B, Majidinia M (2018) Exosomes: natural nanoparticles as bio shuttles for RNAi delivery. J Control Release 289:158–170
pubmed: 30290245
doi: 10.1016/j.jconrel.2018.10.001
Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noël D (2017) Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Sci Rep 7(1):16214
pubmed: 29176667
pmcid: 5701135
doi: 10.1038/s41598-017-15376-8
Zhang S, Chu W, Lai R, Lim S, Hui J, Toh W (2016) Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration. Osteoarthritis Cartil 24(12):2135–2140
doi: 10.1016/j.joca.2016.06.022
Wang Y, Yu D, Liu Z, Zhou F, Dai J, Wu B, Zhou J, Heng BC, Zou XH, Ouyang H (2017) Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Therapy 8(1):189
doi: 10.1186/s13287-017-0632-0
Zhu Y, Wang Y, Zhao B, Niu X, Hu B, Li Q, Zhang J, Ding J, Chen Y, Wang Y (2017) Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis. Stem Cell Res Therapy 8(1):64
doi: 10.1186/s13287-017-0510-9
Ham O, Song B-W, Lee S-Y, Choi E, Cha M-J, Lee CY, Park J-H, Kim I-K, Chang W, Lim S (2012) The role of microRNA-23b in the differentiation of MSC into chondrocyte by targeting protein kinase A signaling. Biomaterials 33(18):4500–4507
pubmed: 22449550
doi: 10.1016/j.biomaterials.2012.03.025
Ning G, Liu X, Dai M, Meng A, Wang Q (2013) MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. Dev Cell 24(3):283–295
pubmed: 23410941
doi: 10.1016/j.devcel.2012.12.016
Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK (2013) MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Therapy 15(1):R28
doi: 10.1186/ar4164
Lin Z, Rodriguez NE, Zhao J, Ramey AN, Hyzy SL, Boyan BD, Schwartz Z (2016) Selective enrichment of microRNAs in extracellular matrix vesicles produced by growth plate chondrocytes. Bone 88:47–55
pubmed: 27080510
pmcid: 4899086
doi: 10.1016/j.bone.2016.03.018
Mao G, Hu S, Zhang Z, Wu P, Zhao X, Lin R, Liao W, Kang Y (2018) Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8. J Cell Mol Med 22(11):5354–5366
pubmed: 30063117
pmcid: 6201229
doi: 10.1111/jcmm.13808
Meng F, Li Z, Zhang Z, Yang Z, Kang Y, Zhao X, Long D, Hu S, Gu M, He S (2018) MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3. Theranostics 8(10):2862
pubmed: 29774080
pmcid: 5957014
doi: 10.7150/thno.23547
Mao G, Zhang Z, Hu S, Zhang Z, Chang Z, Huang Z, Liao W, Kang Y (2018) Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A. Stem Cell Res Therapy 9(1):247
doi: 10.1186/s13287-018-1004-0
Tao S-C, Yuan T, Zhang Y-L, Yin W-J, Guo S-C, Zhang C-Q (2017) Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model. Theranostics 7(1):180
pubmed: 28042326
pmcid: 5196895
doi: 10.7150/thno.17133
Liu X, Shortt C, Huang X, Cowman MK, Kirsch T The potential role of extracellular vesicles released from chondrocytes and stem cells in cartilage repair and osteoarthritis
Liu Y, Lin L, Zou R, Wen C, Wang Z, Lin F (2018) MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis. Cell Cycle 17:2411
pubmed: 30324848
pmcid: 6342066
doi: 10.1080/15384101.2018.1526603
Liu Y, Zou R, Wang Z, Wen C, Zhang F, Lin F (2018) Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis. Biochem J 475:3629
pubmed: 30341166
doi: 10.1042/BCJ20180675
Jin Z, Ren J, Qi S (2020) Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2. Int Immunopharmacol 78:105946. https://doi.org/10.1016/j.intimp.2019.105946
doi: 10.1016/j.intimp.2019.105946
pubmed: 31784400
Wu J, Kuang L, Chen C, Yang J, Zeng WN, Li T, Chen H, Huang S, Fu Z, Li J, Liu R, Ni Z, Chen L, Yang L (2019) miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomaterials 206:87–100. https://doi.org/10.1016/j.biomaterials.2019.03.022
doi: 10.1016/j.biomaterials.2019.03.022
pubmed: 30927715