Tunable Bidirectional Electroosmotic Flow for Diffusion-Based Separations.
diffusion-based separations
diffusivity
electrokinetics
fractionation
microfluidics
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
27 07 2020
27 07 2020
Historique:
received:
30
12
2019
revised:
04
03
2020
pubmed:
12
4
2020
medline:
12
4
2020
entrez:
12
4
2020
Statut:
ppublish
Résumé
We present a new concept for on-chip separation that leverages bidirectional flow, to tune the dispersion regime of molecules and particles. The system can be configured so that low diffusivity species experience a ballistic transport regime and are advected through the chamber, whereas high diffusivity species experience a diffusion dominated regime with zero average velocity and are retained in the chamber. We detail the means of achieving bidirectional electroosmotic flow using an array of alternating current (AC) field-effect electrodes, experimentally demonstrate the separation of particles and antibodies from dyes, and present a theoretical analysis of the system, providing engineering guidelines for its design and operation.
Identifiants
pubmed: 32277549
doi: 10.1002/anie.201916699
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12894-12899Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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