Cluster of Coronavirus Disease 2019 (COVID-19) in the French Alps, February 2020.
COVID-19
SARS-CoV-2
cluster
coronavirus
infection
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
received:
05
03
2020
accepted:
09
04
2020
pubmed:
12
4
2020
medline:
11
8
2020
entrez:
12
4
2020
Statut:
ppublish
Résumé
On 7 February 2020, French Health authorities were informed of a confirmed case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected in Singapore who had recently stayed in a chalet in the French Alps. We conducted an investigation to identify secondary cases and interrupt transmission. We defined as a confirmed case a person linked to the chalet with a positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2. The index case stayed 4 days in the chalet with 10 English tourists and a family of 5 French residents; SARS-CoV-2 was detected in 5 individuals in France, 6 in England (including the index case), and 1 in Spain (overall attack rate in the chalet: 75%). One pediatric case, with picornavirus and influenza A coinfection, visited 3 different schools while symptomatic. One case was asymptomatic, with similar viral load as that of a symptomatic case. Seven days after the first cases were diagnosed, 1 tertiary case was detected in a symptomatic patient with from the chalet a positive endotracheal aspirate; all previous and concurrent nasopharyngeal specimens were negative. Additionally, 172 contacts were monitored; all contacts tested for SARS-CoV-2 (N = 73) were negative. The occurrence in this cluster of 1 asymptomatic case with similar viral load as a symptomatic patient suggests transmission potential of asymptomatic individuals. The fact that an infected child did not transmit the disease despite close interactions within schools suggests potential different transmission dynamics in children. Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspected cases of coronavirus disease 2019.
Sections du résumé
BACKGROUND
On 7 February 2020, French Health authorities were informed of a confirmed case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected in Singapore who had recently stayed in a chalet in the French Alps. We conducted an investigation to identify secondary cases and interrupt transmission.
METHODS
We defined as a confirmed case a person linked to the chalet with a positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2.
RESULTS
The index case stayed 4 days in the chalet with 10 English tourists and a family of 5 French residents; SARS-CoV-2 was detected in 5 individuals in France, 6 in England (including the index case), and 1 in Spain (overall attack rate in the chalet: 75%). One pediatric case, with picornavirus and influenza A coinfection, visited 3 different schools while symptomatic. One case was asymptomatic, with similar viral load as that of a symptomatic case. Seven days after the first cases were diagnosed, 1 tertiary case was detected in a symptomatic patient with from the chalet a positive endotracheal aspirate; all previous and concurrent nasopharyngeal specimens were negative. Additionally, 172 contacts were monitored; all contacts tested for SARS-CoV-2 (N = 73) were negative.
CONCLUSIONS
The occurrence in this cluster of 1 asymptomatic case with similar viral load as a symptomatic patient suggests transmission potential of asymptomatic individuals. The fact that an infected child did not transmit the disease despite close interactions within schools suggests potential different transmission dynamics in children. Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspected cases of coronavirus disease 2019.
Identifiants
pubmed: 32277759
pii: 5819060
doi: 10.1093/cid/ciaa424
pmc: PMC7184384
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
825-832Investigateurs
Elise Brottet
(E)
Delphine Casamatta
(D)
Yves Gallien
(Y)
Scarlett George
(S)
Delphine Viriot
(D)
Fatima Ait Belghiti
(F)
Sibylle Bernard-Stoecklin
(S)
Jean-Claude Desenclos
(JC)
Coralie Giese
(C)
Didier Ghislain
(D)
Magali Gounon
(M)
Nathalie Grangeret
(N)
Cécile Marie
(C)
Bruno Morel
(B)
Muriel Deher
(M)
Anne-Sophie Ronnaux Baron
(AS)
Geneviève Courbis
(G)
Nathalie Ragozin
(N)
Monika Wolska
(M)
Eric Serange
(E)
Delphine Mercatello
(D)
Soraya Aiouaz
(S)
Martine Valette
(M)
Emilie Frobert
(E)
Laurence Josset
(L)
Vanessa Escuret
(V)
Florence Morfin
(F)
Geneviève Billaud
(G)
Myriam Blanc
(M)
Julie Arata-Bardet
(J)
Marie Froidure
(M)
Marion Le Maréchal
(M)
Patricia Pavese
(P)
Isabelle Pierre
(I)
Agathe Becker
(A)
Pierre Chauvelot
(P)
Anne Conrad
(A)
Tristan Ferry
(T)
Patrick Miailhes
(P)
Thomas Perpoint
(T)
Cécile Pouderoux
(C)
Sandrine Roux
(S)
Florent Valour
(F)
Marie-France Lutz
(MF)
Anne Pouvaret
(A)
Virginie Vitrat
(V)
Mylène Maillet
(M)
Cécile Janssen
(C)
Emilie Piet
(E)
Alexie Bosch
(A)
Anne-Laure Destrem
(AL)
Margaux Isnard
(M)
Thibault Challan-Belval
(T)
Chloe Wackenheim
(C)
Alice Couturier
(A)
Gael Gheno
(G)
Thierry Roupioz
(T)
Nicolas Lucet
(N)
Stéphane Ayouni
(S)
Mireille Vincent
(M)
Servicio de Epidemiología
(S)
Dirección General de Salud Pública Del Gover Balear
(D)
Virginie Masserey Spicher
(V)
Catherine Bourquin
(C)
Jeanine Stoll
(J)
Pascal Chaud
(P)
Anne-Laure Mounayar
(AL)
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.