Systems metabolomics: from metabolomic snapshots to design principles.
Journal
Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
20
01
2020
revised:
11
02
2020
accepted:
18
02
2020
pubmed:
12
4
2020
medline:
24
10
2020
entrez:
12
4
2020
Statut:
ppublish
Résumé
Metabolomics is a rapidly expanding technology that finds increasing application in a variety of fields, form metabolic disorders to cancer, from nutrition and wellness to design and optimization of cell factories. The integration of metabolic snapshots with metabolic fluxes, physiological readouts, metabolic models, and knowledge-informed Artificial Intelligence tools, is required to obtain a system-level understanding of metabolism. The emerging power of multi-omic approaches and the development of integrated experimental and computational tools, able to dissect metabolic features at cellular and subcellular resolution, provide unprecedented opportunities for understanding design principles of metabolic (dis)regulation and for the development of precision therapies in multifactorial diseases, such as cancer and neurodegenerative diseases.
Identifiants
pubmed: 32278263
pii: S0958-1669(20)30029-X
doi: 10.1016/j.copbio.2020.02.013
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
190-199Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.