Artificial sweeteners impair endothelial vascular reactivity: Preliminary results in rodents.
Adiposity
/ drug effects
Animals
Aorta
/ drug effects
Dose-Response Relationship, Drug
Endothelium, Vascular
/ drug effects
Preliminary Data
Rats, Wistar
Subcutaneous Fat
/ drug effects
Sucrose
/ administration & dosage
Sweetening Agents
/ administration & dosage
Thiazines
/ administration & dosage
Vasodilation
/ drug effects
Artificial sweeteners
Endothelium
Metabolic disease
Vascular reactivity
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
07 05 2020
07 05 2020
Historique:
received:
30
08
2019
revised:
24
01
2020
accepted:
27
01
2020
pubmed:
13
4
2020
medline:
21
7
2020
entrez:
13
4
2020
Statut:
ppublish
Résumé
Prospective epidemiological studies highlighted recently the link between artificial sweeteners (AS) consumption and the risk of developing cardiometabolic diseases. However, underlying mechanisms remain unknown. Thus, the aim of this preliminary study was to characterize, in a healthy rat population, the effect of chronic AS consumption on body composition and vascular function, an early marker for cardiovascular disease. Healthy Wistar rats followed a 10-week standard diet including the consumption of water sweetened or not with a sucralose/acesulfame potassium solution at different concentrations: for moderate consumption at 1 and 2 mg.kg Both groups of AS-treated rats showed a significant increase in subcutaneous and perirenal adipose tissue mass storage, without changes in total body mass. However, rats that have consumed AS at Acceptable Daily Intake (ADI) concentration revealed a significant vascular endothelial dysfunction compared to other groups. These results are interesting because they will help to better explain the observed increase in cardiometabolic risk.
Sections du résumé
BACKGROUND AND AIMS
Prospective epidemiological studies highlighted recently the link between artificial sweeteners (AS) consumption and the risk of developing cardiometabolic diseases. However, underlying mechanisms remain unknown. Thus, the aim of this preliminary study was to characterize, in a healthy rat population, the effect of chronic AS consumption on body composition and vascular function, an early marker for cardiovascular disease.
METHODS AND RESULTS
Healthy Wistar rats followed a 10-week standard diet including the consumption of water sweetened or not with a sucralose/acesulfame potassium solution at different concentrations: for moderate consumption at 1 and 2 mg.kg
CONCLUSION
Both groups of AS-treated rats showed a significant increase in subcutaneous and perirenal adipose tissue mass storage, without changes in total body mass. However, rats that have consumed AS at Acceptable Daily Intake (ADI) concentration revealed a significant vascular endothelial dysfunction compared to other groups. These results are interesting because they will help to better explain the observed increase in cardiometabolic risk.
Identifiants
pubmed: 32278610
pii: S0939-4753(20)30047-8
doi: 10.1016/j.numecd.2020.01.014
pii:
doi:
Substances chimiques
Sweetening Agents
0
Thiazines
0
Sucrose
57-50-1
trichlorosucrose
96K6UQ3ZD4
acetosulfame
MA3UYZ6K1H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
843-846Informations de copyright
Copyright © 2020 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.