Vagus nerve stimulation and Neurotrophins: a biological psychiatric perspective.
BDNF
Brain plasticity
NGF
Neurogenesis
Psychiatric disorders
Stress
Vagus nerve
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
11
2019
revised:
31
03
2020
accepted:
31
03
2020
pubmed:
13
4
2020
medline:
22
6
2021
entrez:
13
4
2020
Statut:
ppublish
Résumé
Since 2004, vagus nerve stimulation (VNS) has been used in treatment-resistant or treatment-intolerant depressive episodes. Today, VNS is suggested as possible therapy for a larger spectrum of psychiatric disorders, including schizophrenia, obsessive compulsive disorders, and panic disorders. Despite a large body of literature supports the application of VNS in patients' treatment, the exact mechanism of action of VNS remains not fully understood. In the present study, the major knowledges on the brain areas and neuronal pathways regulating neuroimmune and autonomic response subserving VNS effects are reviewed. Furthermore, the involvement of the neurotrophins (NTs) Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) in vagus nerve (VN) physiology and stimulation is revised. The data on brain NGF/BDNF synthesis and in turn on the activity-dependent plasticity, connectivity rearrangement and neurogenesis, are presented and discussed as potential biomarkers for optimizing stimulatory parameters for VNS. A vagus nerve-neurotrophin interaction model in the brain is finally proposed as a working hypothesis for future studies addressed to understand pathophysiology of psychiatric disturbance.
Identifiants
pubmed: 32278791
pii: S0149-7634(19)31051-6
doi: 10.1016/j.neubiorev.2020.03.034
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
338-353Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.