Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Effect of Beam Size Changes and Dose Effect at Constant Collimation.
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
09
10
2019
revised:
09
03
2020
accepted:
16
03
2020
pubmed:
13
4
2020
medline:
16
2
2021
entrez:
13
4
2020
Statut:
ppublish
Résumé
Stereotactic body radiation therapy is a therapeutic option offered to high surgical risk patients with lung cancer. Focal lung irradiation in mice is a new preclinical model to help understand the development of lung damage in this context. Here we developed a mouse model of lung stereotactic therapy using arc delivery and monitored the development of lung damage while varying the beam size and dose delivered. C57BL/6JRj mice were exposed to 90 Gy focal irradiation on the left lung using 1-mm diameter, 3 × 3 mm Both 1-mm diameter and 3 × 3 mm Arc therapy allows long-term studies and dose escalation without lethality. In our dose-delivery conditions, dose-effect studies revealed that 3 × 3 mm
Identifiants
pubmed: 32278852
pii: S0360-3016(20)30934-2
doi: 10.1016/j.ijrobp.2020.03.011
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
548-562Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.